Antifolate Antifolate

Inhibitors

Cat.No.	Name	Information
M2711	Folinic acid calcium salt	Folic acid is an adjuvant compound used in cancer chemotherapy. *The compound is unstable in solutions, freshly prepared is recommended
M13588	Methotrexate disodium	Methotrexate (Amethopterin) disodium, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis.
M13587	Folinic acid	Folinic acid (Leucovorin) is a biological folic acid and is generally administered along with methotrexate (MTX) as a rescue agent to decrease MTX-induced toxicity.
M7108	Pemetrexed	Pemetrexed is a thymidylate synthetase inhibitor, also inhibits dihydrofolate reductase, GARFT and AICART.
M5866	Pemetrexed Disodium Hydrate	Pemetrexed Disodium Hydrate is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM, respectively.
M3303	Pralatrexate	Pralatrexate is an antifolate, and structurally a folate analog. Its IC50 is < 300 nM in some cell lines.
M3090	Trimethoprim	Trimethoprim is a bacteria-suppressing antibiotic used to prevent and study urinary tract infections.
M2711	Folinic acid calcium salt	Folic acid is an adjuvant compound used in cancer chemotherapy. *The compound is unstable in solutions, freshly prepared is recommended
M2228	Abitrexate (Methotrexate)	Abitrexate is an antimetabolite and antifolate agent with antineoplastic and immunosuppressant activities.