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Antifolate Antifolate

Inhibitors

Cat.No.  Name Information
M2711 Folinic acid calcium salt Folic acid is an adjuvant compound used in cancer chemotherapy. *The compound is unstable in solutions, freshly prepared is recommended
M13588 Methotrexate disodium Methotrexate (Amethopterin) disodium, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis.
M13587 Folinic acid Folinic acid (Leucovorin) is a biological folic acid and is generally administered along with methotrexate (MTX) as a rescue agent to decrease MTX-induced toxicity.
M7108 Pemetrexed Pemetrexed is a thymidylate synthetase inhibitor, also inhibits dihydrofolate reductase, GARFT and AICART.
M5866 Pemetrexed Disodium Hydrate Pemetrexed Disodium Hydrate is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM, respectively.
M3303 Pralatrexate Pralatrexate is an antifolate, and structurally a folate analog. Its IC50 is < 300 nM in some cell lines.
M3090 Trimethoprim Trimethoprim is a bacteria-suppressing antibiotic used to prevent and study urinary tract infections.
M2711 Folinic acid calcium salt Folic acid is an adjuvant compound used in cancer chemotherapy. *The compound is unstable in solutions, freshly prepared is recommended
M2228 Abitrexate (Methotrexate) Abitrexate is an antimetabolite and antifolate agent with antineoplastic and immunosuppressant activities.



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