| Cat.No. | Name | Information |
|---|---|---|
| M2711 | Folinic acid calcium salt | Folic acid is an adjuvant compound used in cancer chemotherapy. *The compound is unstable in solutions, freshly prepared is recommended |
| M13587 | Folinic acid | Folinic acid (Leucovorin) is a biological folic acid and is generally administered along with methotrexate (MTX) as a rescue agent to decrease MTX-induced toxicity. |
| M9787 | Aminopterin | Aminopterin is a folic acid derivative used as a rodenticide that has been shown to be teratogenic, and a dihydrofolate reductase inhibitor used to treat rheumatoid arthritis and leukemia. |
| M7108 | Pemetrexed | Pemetrexed is a thymidylate synthetase inhibitor, also inhibits dihydrofolate reductase, GARFT and AICART. |
| M6109 | Calcium N5-methyltetrahydrofolate | Calcium N5-methyltetrahydrofolate(NSC173328) is the calcium salt of levomefolic acid, which has been proposed for treatment of cardiovascular disease and advanced cancers such as breast and colorectal cancers. |
| M6108 | Levomefolate calcium | Levomefolate is an artificial form of folate. |
| M5866 | Pemetrexed Disodium Hydrate | Pemetrexed Disodium Hydrate is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM, respectively. |
| M5662 | Folinic acid calcium salt pentahydrate | Folinic Acid pentahydrate is a reduced form of Folinic Acid that can be used in combination with other chemotherapy-like compounds. *The compound is unstable in solutions, freshly prepared is recommended |
| M3303 | Pralatrexate | Pralatrexate is an antifolate, and structurally a folate analog. Its IC50 is < 300 nM in some cell lines. |
| M3262 | Methotrexate metabolite | Methotrexate metabolite is a dihydrofolate reductase potent inhibitor with an IC50 of 1 nM. |
| M3254 | Pyrimethamine | Pyrimethamine is a dihydrofolate reductase(DHFR) inhibitor with an IC50 of 15.4 nM. |
| M3090 | Trimethoprim | Trimethoprim is a bacteria-suppressing antibiotic used to prevent and study urinary tract infections. |
| M3040 | Sulfamethazine | Sulfamethazine is a sulfonamide antibacterial. |
| M2228 | Abitrexate (Methotrexate) | Abitrexate is an antimetabolite and antifolate agent with antineoplastic and immunosuppressant activities. |
| M2034 | Pemetrexed disodium | Pemetrexed is a novel antifolic acid antimetabolic compound with K I of 1.3 nM, 7.2 nM, and 65 nM for TS, DHFR, and GARFT, respectively. |
| M30659 | Trimetrexate glucuronate | Trimetrexate glucuronate (NSC 352122) is a folic acid antagonist. Trimetrexate glucuronate affects DNA and RNA synthesis by inhibiting dihydrofolate reductase and preventing the synthesis of purine nucleotides and thymidylate. Trimetrexate glucuronate has potential antitumour activity and can also be used to inhibit Pneumocystis carinii pneumonia. |
| M29977 | Pemetrexed disodium heptahydrate | Pemetrexed disodium heptahydrate is a novel antifolate, the Ki values of the pentaglutamate of LY231514 are 1.3, 7.2, and 65 nM for inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), respectively. |
| M29261 | Fanotaprim | Fanotaprim is a dihydrofolate reductase (DHFR) inhibitor with IC50s of 1.57 and 308 nM for tgDHFR (Toxoplasma gondii DHFR) and hDHFR (human DHFR), respectively. Fanotaprim has the potential for the research of toxoplasmosis. |
| M29037 | LSN 3213128 | LSN 3213128 is a selective, nonclassical, orally bioavailable antifolate with potent and specific inhibitory activity for aminoimidazole-4-carboxamide ribonucleotide formyltransferase (AICARFT), with IC50 of 16 nM for AICARFT enzyme inhibiton and 19 nM in cells. Anti-tumor activity. |
| M28430 | Lometrexol hydrate | Lometrexol (DDATHF) hydrate, an antipurine antifolate, can inhibit the activity of glycinamide ribonucleotide formyltransferase (GARFT) but do not induce detectable levels of DNA strand breaks. Lometrexol hydrate can further inhibit de novo purine synthesis, causing abnormal cell proliferation and apoptosis, even cell cycle arrest. Lometrexol hydrate has anticancer activity. Lometrexol hydrate also is a potent human Serine hydroxymethyltransferase1/2 (hSHMT1/2) inhibitor. |
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