| Cat.No. | Name | Information |
|---|---|---|
| M2711 | Folinic acid calcium salt | Folic acid is an adjuvant compound used in cancer chemotherapy. *The compound is unstable in solutions, freshly prepared is recommended |
| M27736 | Lometrexol | Lometrexol (DDATHF), an antipurine antifolate, can inhibit the activity of glycinamide ribonucleotide formyltransferase (GARFT) but do not induce detectable levels of DNA strand breaks. Lometrexol can further inhibit de novo purine synthesis, causing abnormal cell proliferation and apoptosis, even cell cycle arrest. Lometrexol has anticancer activity. Lometrexol also is a potent human Serine hydroxymethyltransferase1/2 (hSHMT1/2) inhibitor. |
| M24691 | Mirvetuximab | Mirvetuximab (M9346A) is an anti-FOLR1 (folate receptor 1) monoclonal antibody. Mirvetuximab is the antibody moiety of novel folate receptor alpha (FRα)-targeting ADC (Mirvetuximab soravtansine). Mirvetuximab soravtansine can be used in ovarian and other FRα-positive cancer research. |
| M13588 | Methotrexate disodium | Methotrexate (Amethopterin) disodium, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. |
| M13587 | Folinic acid | Folinic acid (Leucovorin) is a biological folic acid and is generally administered along with methotrexate (MTX) as a rescue agent to decrease MTX-induced toxicity. |
| M9787 | Aminopterin | Aminopterin is a folic acid derivative used as a rodenticide that has been shown to be teratogenic, and a dihydrofolate reductase inhibitor used to treat rheumatoid arthritis and leukemia. |
| M7108 | Pemetrexed | Pemetrexed is a thymidylate synthetase inhibitor, also inhibits dihydrofolate reductase, GARFT and AICART. |
| M6109 | Calcium N5-methyltetrahydrofolate | Calcium N5-methyltetrahydrofolate(NSC173328) is the calcium salt of levomefolic acid, which has been proposed for treatment of cardiovascular disease and advanced cancers such as breast and colorectal cancers. |
| M6108 | Levomefolate calcium | Levomefolate is an artificial form of folate. |
| M5866 | Pemetrexed Disodium Hydrate | Pemetrexed Disodium Hydrate is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM, respectively. |
| M5662 | Folinic acid calcium salt pentahydrate | Folinic Acid pentahydrate is a reduced form of Folinic Acid that can be used in combination with other chemotherapy-like compounds. *The compound is unstable in solutions, freshly prepared is recommended |
| M3303 | Pralatrexate | Pralatrexate is an antifolate, and structurally a folate analog. Its IC50 is < 300 nM in some cell lines. |
| M3262 | Methotrexate metabolite | Methotrexate metabolite is a dihydrofolate reductase potent inhibitor with an IC50 of 1 nM. |
| M3254 | Pyrimethamine | Pyrimethamine is a dihydrofolate reductase(DHFR) inhibitor with an IC50 of 15.4 nM. |
| M3040 | Sulfamethazine | Sulfamethazine is a sulfonamide antibacterial. |
| M2228 | Methotrexate | Methotrexate (Amethopterin) is an antimetabolite and antifolate agent with antineoplastic and immunosuppressant activities. |
| M2034 | Pemetrexed disodium | Pemetrexed is a novel antifolic acid antimetabolic compound with K I of 1.3 nM, 7.2 nM, and 65 nM for TS, DHFR, and GARFT, respectively. |
| M58379 | Pelitrexol | Pelitrexol (AG 2037) is an inhibitor of glycinamide ribonucleotide formyltransferase (GARFT), a purine biosynthetic enzyme. Pelitrexol also inhibits mTORC1 by reducing GTP-bound Rheb level, a mTORC1 obligate activator. |
| M55915 | Methotrexate α-tert-butyl ester | Methotrexate α-tert-butyl ester, capped by OtBu, significantly reduces tumor growth in HT1080 tumor bearing mice. |
| M30659 | Trimetrexate glucuronate | Trimetrexate glucuronate (NSC 352122) is a folic acid antagonist. Trimetrexate glucuronate affects DNA and RNA synthesis by inhibiting dihydrofolate reductase and preventing the synthesis of purine nucleotides and thymidylate. Trimetrexate glucuronate has potential antitumour activity and can also be used to inhibit Pneumocystis carinii pneumonia. |
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