Inhibitors
Cat.No. | Name | Information |
---|---|---|
M2711 | Folinic acid calcium salt | Folic acid is an adjuvant compound used in cancer chemotherapy. *The compound is unstable in solutions, freshly prepared is recommended |
M13588 | Methotrexate disodium | Methotrexate (Amethopterin) disodium, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. |
M13587 | Folinic acid | Folinic acid (Leucovorin) is a biological folic acid and is generally administered along with methotrexate (MTX) as a rescue agent to decrease MTX-induced toxicity. |
M7108 | Pemetrexed | Pemetrexed is a thymidylate synthetase inhibitor, also inhibits dihydrofolate reductase, GARFT and AICART. |
M5866 | Pemetrexed Disodium Hydrate | Pemetrexed Disodium Hydrate is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM, respectively. |
M3303 | Pralatrexate | Pralatrexate is an antifolate, and structurally a folate analog. Its IC50 is < 300 nM in some cell lines. |
M3090 | Trimethoprim | Trimethoprim is a bacteria-suppressing antibiotic used to prevent and study urinary tract infections. |
M2711 | Folinic acid calcium salt | Folic acid is an adjuvant compound used in cancer chemotherapy. *The compound is unstable in solutions, freshly prepared is recommended |
M2228 | Abitrexate (Methotrexate) | Abitrexate is an antimetabolite and antifolate agent with antineoplastic and immunosuppressant activities. |
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