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Trimetrexate glucuronate

Cat. No. M30659

All AbMole products are for research use only, cannot be used for human consumption.

Trimetrexate glucuronate Structure
Synonym:

CI-898 glucuronate

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Quality Control & Documentation
Biological Activity

Trimetrexate glucuronate (NSC 352122) is a folic acid antagonist. Trimetrexate glucuronate affects DNA and RNA synthesis by inhibiting dihydrofolate reductase and preventing the synthesis of purine nucleotides and thymidylate. Trimetrexate glucuronate has potential antitumour activity and can also be used to inhibit Pneumocystis carinii pneumonia.

Chemical Information
Molecular Weight 563.56
Formula C25H33N5O10
CAS Number 82952-64-5
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] R G Amado, et al. Ann Oncol. Low-dose trimetrexate glucuronate and protracted 5-fluorouracil infusion in previously untreated patients with advanced pancreatic cancer

[2] P J Harris. AIDS Patient Care STDS. Trimetrexate glucuronate associated with anti-Kaposi sarcoma effect

[3] B J Freij, et al. Ann N Y Acad Sci. Pharmacokinetics of trimetrexate glucuronate in infants with AIDS and Pneumocystis carinii pneumonia

[4] D A Hussar. Nursing. New drugs

[5] B K Wong, et al. Drug Metab Dispos. Metabolic disposition of trimetrexate, a nonclassical dihydrofolate reductase inhibitor, in rat and dog

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Keywords: Trimetrexate glucuronate, CI-898 glucuronate supplier, Antifolate, inhibitors, activators

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