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Trimetrexate glucuronate (NSC 352122) is a folic acid antagonist. Trimetrexate glucuronate affects DNA and RNA synthesis by inhibiting dihydrofolate reductase and preventing the synthesis of purine nucleotides and thymidylate. Trimetrexate glucuronate has potential antitumour activity and can also be used to inhibit Pneumocystis carinii pneumonia.
| Molecular Weight | 563.56 |
| Formula | C25H33N5O10 |
| CAS Number | 82952-64-5 |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Related Antifolate Products |
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Folic acid is an adjuvant compound used in cancer chemotherapy. *The compound is unstable in solutions, freshly prepared is recommended |
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Sulfamethazine is a sulfonamide antibacterial. |
| Pralatrexate
Pralatrexate is an antifolate, and structurally a folate analog. It acts as an inhibitor of dihydrofolate reductase. It is selective for the reduced folate carrier type 1. Its IC50 is < 300 nM in some cell lines. |
| Folinic acid calcium salt pentahydrate
Folinic Acid pentahydrate is a reduced form of Folinic Acid that can be used in combination with other chemotherapy-like compounds. *The compound is unstable in solutions, freshly prepared is recommended |
| Levomefolate calcium
Levomefolate is an artificial form of folate. |
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