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Pemetrexed

Cat. No. M7108
Pemetrexed Structure
Synonym:

LY231514

Size Price Availability Quantity
50mg USD 55 In stock
100mg USD 80 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Pemetrexed is a high affinity dihydrofolate reductase inhibitor (Ki = 7 nM). Pemetrexed also inhibits thymidylate synthase, AICART and glycinamide ribonucleotide formyltransferase (Ki values are 109 nM, and 3.5 μM and 9.3 μM, respectively). Indirectly activates AMPK. Pemetrexed inhibits proliferation of cancer cell lines in vitro.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 427.41
Formula C20H21N5O6
CAS Number 137281-23-3
Purity >99%
Solubility DMSO 45 mg/mL
Storage at -20°C
References

Diamidine compounds for selective inhibition of protein arginine methyltransferase 1.
Yan, et al. J Med Chem. 2014;57: 2611. PMID: 24564570.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Pemetrexed, LY231514 supplier, Antifolate, inhibitors

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