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Pemetrexed Disodium Hydrate

Cat. No. M5866
Pemetrexed Disodium Hydrate Structure
Synonym:

Pemetrexed sodium hydrate

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
100mg USD 60 In stock
500mg USD 160 In stock
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Quality Control
Biological Activity

Pemetrexed Disodium Hydrate is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM, respectively.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 516.42
Formula C20H21N5O6.5/2H2O.2Na
CAS Number 357166-30-4
Purity 99.67%
Solubility 90 mg/mL warmed in water
Storage at -20°C
References

New Polymorphic Forms of Pemetrexed Diacid and Their Use for the Preparation of Pharmaceutically Pure Amorphous and Hemipentahydrate Forms of Pemetrexed Disodium.
Michalak O, et al. Molecules. 2015 Jul 30;20(8):13814-29. PMID: 26263958.

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Keywords: Pemetrexed Disodium Hydrate, Pemetrexed sodium hydrate supplier, Antifolate, inhibitors

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