About 7 results found for searched term "Methotrexate" (0.122 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M2228 | Methotrexate | Antifolate |
| Amethopterin; CL14377; WR19039 | ||
| Methotrexate (Amethopterin) is an antimetabolite and antifolate agent with antineoplastic and immunosuppressant activities. | ||
| M3262 | Methotrexate metabolite | Antifolate |
| DAMPA; NSC 131463 | ||
| Methotrexate metabolite is a dihydrofolate reductase potent inhibitor with an IC50 of 1 nM. | ||
| M13588 | Methotrexate disodium | Antifolate |
| Amethopterin disodium; CL14377 disodium; WR19039 disodium | ||
| Methotrexate (Amethopterin) disodium, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. | ||
| M55915 | Methotrexate α-tert-butyl ester | Antifolate |
| Methotrexate α-tert-butyl ester, capped by OtBu, significantly reduces tumor growth in HT1080 tumor bearing mice. | ||
| M5043 | 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine | Others |
| 4-Chloro-7H-pyrrolo[2,3-d] pyrimidine is an important pharmaceutical intermediate, which is widely used in the synthesis of many pharmaceutical intermediates at home and abroad. Including CP690550, CGP76030 and so on, 4-Chloro-7H-pyrrolo[2,3-d] pyrimidine was the scaffold for many commercially available drugs. Also, 4-Chloro-7H-pyrrolo[2,3-d] pyrimidine was the intermediate of the bulk drug, Tofatinib, which was widely used in treatment of adult patients with moderate to severe rheumatoid arthritis with inadequate or intolerant methotrexate response. | ||
| M13587 | Folinic acid | Antifolate |
| leucovorin | ||
| Folinic acid (Leucovorin) is a biological folic acid and is generally administered along with methotrexate (MTX) as a rescue agent to decrease MTX-induced toxicity. | ||
| M30477 | 6,8-Diprenylnaringenin | BCRP/ABCG2/MXR/ABCP |
| Lonchocarpol A; Senegalensin | ||
| 6,8-Diprenylnaringenin (Lonchocarpol A; Senegalensin), a hop prenylflavonoid, is a inhibitor of breast cancer resistance protein (BCRP/ABCG2). 6,8-Diprenylnaringenin inhibits ABCG2-mediated efflux of Mitoxantrone, and 3H-Methotrexate transport (IC50=0.41 μM) in HEK293 cells. 6,8-Diprenylnaringenin exhibits some estrogenicity, but its potency is less than 1% of that of 8-Prenylnaringenin. | ||
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