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Peramivir Trihydrate

Cat. No. M3222
Peramivir Trihydrate Structure
Synonym:

BCX-1812 Trihydrate; RWJ-270201 Trihydrate; S-021812 Trihydrate

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
2mg USD 37  USD37 In stock
5mg USD 75  USD75 In stock
10mg USD 120  USD120 In stock
50mg USD 390  USD390 In stock
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Quality Control & Documentation
Biological Activity

Peramivir Trihydrate is a trihydrate of the anti-infection agent Peramivir Trihydrate which is a transition-state analogue and a potent, specific influenza viral neuraminidase inhibitor with an IC50 of median 0.09 nM. The IC50 for Peramivir Trihydrate is markedly lower than that for either zanamivir or oseltamivir. Peramivir Trihydrate increases survival in preclinical influenza models, including mouse and ferret models of highly pathogenic avian influenza H5N1. One day of treatment with Peramivir Trihydrate is active, and multiple days of treatment rescues most or all mice with H5N1. Similar data have been obtained in ongoing murine experiments with seasonal influenza A (H1N1)/H274Y. 

Product Citations
Chemical Information
Molecular Weight 382.45
Formula C15H28N4O4.3H2O
CAS Number 1041434-82-5
Solubility (25°C) Water 4 mg/mL (Need ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Lu Li, et al. Recommendation of Antimicrobial Dosing Optimization During Continuous Renal Replacement Therapy

[2] No authors listed. Peramivir

[3] No authors listed. Aust Prescr. Peramivir for influenza

[4] Lesley J Scott. Peramivir: A Review in Uncomplicated Influenza

[5] No authors listed. Peramivir

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Keywords: Peramivir Trihydrate, BCX-1812 Trihydrate; RWJ-270201 Trihydrate; S-021812 Trihydrate supplier, Anti-infection, inhibitors, activators


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