All AbMole products are for research use only, cannot be used for human consumption.
Scriptaid is an inhibitor of HDAC. It shows a greater effect on acetylated H4 than H3.
| Cell Experiment | |
|---|---|
| Cell lines | Human breast cancer cells MDA-MB-231 |
| Preparation method | Plating the cells at a cell density of 5000 cells/well in 12 well plates and treating them with scriptaid for up to 3 days. Use a Coulter counter to count the number of cell every day. |
| Concentrations | ~10 μg/mL |
| Incubation time | 3 days |
| Animal Experiment | |
|---|---|
| Animal models | Human breast carcinoma xenografts MDA-MB-231 |
| Formulation | DMSO |
| Dosages | 3.5 mg/kg |
| Administration | intraperitoneally for five consecutive days with 2 days rest each week for a total of 4 weeks |
| Molecular Weight | 326.35 |
| Formula | C18H18N2O4 |
| CAS Number | 287383-59-9 |
| Solubility (25°C) | DMSO 50 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related HDAC Products |
|---|
| CM-444
CM-444 is an inhibitor for HDAC and DNA methyltransferases (DNMT) with IC50 values of 6 nM-0.6 μM and 1.8-2.3 μM, respectively. CM-444 is an inducer for the differentiation of acute myeloid leukemia cells. CM-444 exhibits anti-leukemic activity and improves the survival rate in mouse models. |
| CM-1758
CM-1758 is a histone deacetylase (HDAC) inhibitor. CM-1758 inhibits tumor growth in vivo. CM-1758 induces acetylation of non-histone proteins in acute myeloid leukemia cells. |
| T-518
T-518 is an orally active, selective, and blood-brain barrier permeable HDAC6 inhibitor with an IC50 value of 36 nM for human HDAC6. |
| SE-7552
SE-7552, a 2-(difluoromethyl)-1,3,4-oxadiazole (DFMO) derivative, is an orally active, highly selective, non-hydroxamate HDAC6 inhibitor with an IC50 of 33 nM. |
| BRD9757
BRD9757 is a potent, capless and selective HDAC6 inhibitor with an IC50 of 30 nM. |
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