Scriptaid is an inhibitor of HDAC. It shows a greater effect on acetylated H4 than H3.
Cell Experiment | |
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Cell lines | Human breast cancer cells MDA-MB-231 |
Preparation method | Plating the cells at a cell density of 5000 cells/well in 12 well plates and treating them with scriptaid for up to 3 days. Use a Coulter counter to count the number of cell every day. |
Concentrations | ~10 μg/mL |
Incubation time | 3 days |
Animal Experiment | |
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Animal models | Human breast carcinoma xenografts MDA-MB-231 |
Formulation | DMSO |
Dosages | 3.5 mg/kg |
Administration | intraperitoneally for five consecutive days with 2 days rest each week for a total of 4 weeks |
Molecular Weight | 326.35 |
Formula | C18H18N2O4 |
CAS Number | 287383-59-9 |
Solubility (25°C) | DMSO 50 mg/mL |
Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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