About 30 results found for searched term "Cytokines" (0.17 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1999 | Vadimezan (DMXAA) | STING |
| ASA404; DMXAA | ||
| Vadimezan (DMXAA; ASA-404) acts as a tumor vascular disrupting agent (tumor-VDA), is also a murine agonist of the stimulator of interferon genes (STING) and also a potent inducer of type I IFNs and other cytokines. | ||
| M4131 | Ophiopogonin-D | PPAR |
| 65604-80-0; 945619-74-9 | ||
| Ophiopogonin D, isolated from the tuber of Ophiopogon japonicus, is a rare naturally occurring C29 steroid glycoside. Ophiopogonin D is a CYP2J3 inducer. By increasing the expression of CYP2J2/EETs and PPARα in human umbilical vein endothelial cells (HUVECs), Ophiopogonin D significantly inhibited Ang Ii-induced NF-κB nuclear translocation and IκBα down-regulation. Intracellular Ca2+ overload and activation of pro-inflammatory cytokines. | ||
| M4276 | Tyrosol | NF-κB |
| Tyrosol is a derivative of phenyl ethanol. Tyrosol attenuates pro-inflammatory cytokines from astrocytes and decreases NF-κB activation. It has antioxidant and anti-inflammatory effects. | ||
| M4539 | Polygalasaponin-F | TLR |
| Polygalasaponin F is an oleanane type triterpenoid saponin extracted from Polygala Japonica, which can reduce the release of inflammatory cytokine tumor necrosis factor α (TNFa). Polygalasaponin F reduces the secretion of neuroinflammatory cytokines by regulating the TLR4-PI3K/ Akt-NF-KB signaling pathway. | ||
| M4897 | AICAR | AMPK |
| Acadesine; AICA Riboside | ||
| AICAR is an adenosine analog and activator of AMPK that regulates glucose and lipid metabolism and inhibits the production of pro-inflammatory cytokines and iNOS. In addition, AICAR is an inhibitor of autophagy, YAP and mitophagy. | ||
| M4940 | SC75741 | NF-κB |
| SC-75741 | ||
| SC75741 is a broad and potent INHIBITOR of NF-κB with an IC50 of 200 nM against P65. SC75741 blocks replication of influenza viruses. SC75741 leads to decreased expression of cytokines, chemokines, and pro-apoptotic factors by impairing DNA binding of NF-κB subunit P65. Inhibit caspase activation and block caspase-mediated nuclear output of viralribonucleoproteins. | ||
| M5472 | Butoconazole nitrate | Anti-infection |
| RS-35887 | ||
| Butoconazole (RS-35887) is an antifungal agent that inhibits phA-stimulated secretion of cytokines such as IL-2, TNFα, IFN and GM-CSF in human peripheral blood lymphocytes. IC50 were 7.2 μg/mL, 14.4 μg/mL, 7.36 μg/mL and 7.6 μg/mL, respectively. | ||
| M5808 | Naphazoline HCl | Adrenergic Receptor |
| Naphazoline hydrochloride is a potent alpha-adrenergic receptor agonist. Naphazoline hydrochloride reduces levels of inflammatory factors (TNF-α, IL-1β, and IL-6), cytokines (IFN-γ and IL-4), IgE, GMCSF, and NGF, and is used in studies of non-bacterial conjunctivitis. Naphazoline hydrochloride can be used in studies of non-bacterial conjunctivitis. | ||
| M5827 | Oclacitinib maleate | JAK |
| PF-03394197 | ||
| Oclacitinib is a novel inhibitor of JAK family members with IC50 ranging from 10 to 99 nM and JAK1-dependent cytokines with IC50 ranging from 36 to 249 nM, which did not inhibit a panel of 38 non-JAK kinases. | ||
| M6215 | TAPI-0 | MMP |
| TAPI-0 is an inhibitor which blocks the maturation of cytokines, soluble cyokine receptors and other proteins that require the action of proteases. | ||
| M6297 | Upadacitinib | JAK |
| ABT-494 | ||
| Upadacitinib (ABT-494) is a potent, orally active and selective Janus kinase 1 (JAK1) inhibitor (IC50=43 nM). Upadacitinib (ABT-494) displays approximately 74 fold selective for JAK1 over JAK2 (200 nM) in cellular assays dependent on specific, relevant cytokines. Upadacitinib (ABT-494) can be used for several autoimmune disorders research. | ||
| M7189 | Resiquimod | TLR |
| R848; S28463 | ||
| Resiquimod is a agonist of Toll-like receptors 7 and 8 (TLR7/TLR8) that induces upregulation of cytokines such as TNF-α, IL-6 and IFN-α. | ||
| M7625 | Binucleine 2 | Others |
| Binucleine 2 is a cytokinesis inhibitor. | ||
| M8594 | BRD3308 | HDAC |
| BRD3308 is a highly selective HDAC3 inhibitor with an IC50 of 54 nM. BRD3308 is 23 times more selective to HDAC3 than HDAC1 (IC50:1.26 μM) or HDAC2 (IC50:1.34 μM). BRD3308 inhibits pancreatic β cell apoptosis induced by inflammatory cytokines or glucolipid toxic stress and increases functional insulin release. BRD3308 also activates HIV-1 transcription and disrupts HIV-1 latency. | ||
| M8770 | Didox | Others |
| N,3,4-Trihydroxybenzamide | ||
| Didox is a ribonucleotide reductase (RNR) inhibitor that inhibits proliferation of and decreased secretion of cytokines IL-6, IFN-g, TNF-a, IL-2, IL-13, IL-10 and IL-4. | ||
| M9827 | Recombinant Human Oncostatin M Protein (HEK293) | Recombinant Proteins |
| OSM | ||
| Oncostatin M (HEK293) is also known as OSM, is a glycoprotein belonging to the interleukin-6 family of cytokines that has functions mainly in cell growth. | ||
| M10349 | Dihydrocytochalasin B | Actin-Related Protein |
| Dihydrocytochalasin B is a Cytokinesis inhibitor and changes the morphology of the cells, similar to that of cytochalasin B. | ||
| M10430 | Recombinant Human TGF-α (E. coli) | Recombinant Proteins |
| Human Transforming Growth Factor-alpha | ||
| Recombinant human TGF-α, also known as sarcoma growth factor, TGF- I and ETGF, is a member of the EGF family of cytokines. TGF-α promotes the proliferation of various epidermal and epithelial cells through EGFR signaling and synergistic action with TGF- β. Expressed by Escherichia coli. | ||
| M10611 | QS-21 | Adjuvants |
| QS-21 ADJUVANT; Stimulon | ||
| QS-21, an immunostimulatory saponin, could be used as a potent vaccine adjuvant. QS-21 stimulates Th2 humoral and Th1 cell-mediated immune responses through action on antigen presenting cells (APCs) and T cells. QS-21 can activate the NLRP3 inflammasome with subsequent release of caspase-1 dependent cytokines, IL-1β and IL-18. | ||
| M10634 | NE 52-QQ57 | GPR/FFAR |
| NE52QQ57 | ||
| NE 52-QQ57 is an orally available GPR4 antagonist with an IC50 of 70 nM. NE 52-QQ57 significantly inhibited the AGE-induced increased expression of several key inflammatory cytokines and signaling molecules, including tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-6, inducible nitric oxide synthase (iNOS), nitric oxide (NO), cyclooxygenase 2 (COX2), and prostaglandin E2 (PGE2). | ||
| M10905 | Pralnacasan | Caspase |
| VX-740; HMR 3480 | ||
| Pralnacasan (VX-740) is a potent, selective, non-peptide inhibitor with an oral active interleukin 1β-convertase (ICE, caspase 1) inhibitor,Ki 1.4 nM. Pralnacasan inhibits pro-inflammatory cytokines IL-18, IL-1β, and IFN-γ. Pralnacasan has the potential to be used in the study of osteoarthritis and rheumatoid arthritis. | ||
| M10941 | Tapinarof | Aryl hydrocarbon Receptor |
| WBI-1001; Benvitimod; GSK2894512 | ||
| Tapinarof (WBI-1001) is a Frist in class aromatic hydrocarbon receptor (AhR) agonist with EC50 of 13 nM. Tapinarof reduced skin inflammation in mice. It can effectively inhibit inflammatory cytokines, regulate skin barrier protein expression and antioxidant activity. | ||
| M11181 | 2,5-Dihydroxyacetophenone | ERK |
| DHAP, 2-Acetylhydroquinone, Quinacetophenone | ||
| 2',5'-Dihydroxyacetophenone (DHAP, 2-Acetylhydroquinone, Quinacetophenone) is a mixture of dihydroxyacetophenone isomers used in food flavoring. 2',5'-Dihydroxyacetophenone significantly inhibits the production of NO by inhibiting the expression of iNOS. 2',5'-Dihydroxyacetophenone significantly reduces the expression levels of the pro-inflammatory cytokines TNF-α and IL-6 by blocking the ERK1/2 and NF-κB signaling pathways. | ||
| M19881 | Benznidazole | Anti-infection |
| Radanil | ||
| Benznidazole is a nitroimidazole derivative having an antiprotozoal activity by interfering with parasite protein biosynthesis, influencing cytokines production and stimulating host phagocytosis. | ||
| M20753 | TBOPP | Others |
| TBOPP is a selective inhibitor of dedicator of cytokinesis (DOCK1, Dock180) that inhibits DOCK1-mediated Rac activation with IC50 of 8.4 μM. TBOPP binds to the DOCK1 DHR-2 domain with Kd of 7.1 μM. TBOPP exhibits anti-tumor activity. | ||
| M21046 | Bakkenolide A | Others |
| Fukinanolid | ||
| Bakkenolide A, extracted from Petasites tricholobus, has been suggested to against cancer and display protective effects on inflammatory cytokines formation. | ||
| M21112 | Trofinetide acetate | Peptides |
| NNZ-2566 acetate | ||
| Trofinetide (NNZ-2566) acetate is a novel analogue of the amino-terminal tripeptide of IGF-1, stimulates synaptic maturation, inhibits the production of inflammatory cytokines and the hyperactivation of microglia and astrocytes, and increases the amount of available IGF-1 that can bind to the IGF-1 receptor. Sequence: G-α-Me-Pro-E. | ||
| M21121 | Recombinant Rat IL-10 (CHO) | Recombinant Proteins |
| B-TCGF; CSIF; TGIF | ||
| Interleukin-10 (IL-10) is produced by many immune cells, such as T-cells, macrophages, mast cells and dendritic cells. It is usually secreted as a homodimer and, upon binding to its receptor, inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and Th2 cells. | ||
| M21166 | Recombinant Human IL32 (E.coli) | Recombinant Proteins |
| Natural killer cells protein 4；Tumor necrosis factor alpha-inducing factor | ||
| It induces various cytokines such as TNFA/TNF-α and IL8. it activates the typical cytokine signaling pathways NF-kappa-B and p38 MAPK. accession # P24001. | ||
| M21402 | Recombinant Mouse IL-27 (Mammalian, C-6His) | Recombinant Proteins |
| Interleukin-27 subunit alpha; IL-27 subunit alpha | ||
| IL-27 is a heterodimeric cytokine which belongs to the IL-6/IL-12 family of long type I cytokines. Recombinant Mouse Interleukin-27 Subunit Alpha and Interleukin-27 Subunit Beta expressed the target gene encoding Tyr19-Pro228&Phe29-Ser234 with a 6His tag at the C-terminus. | ||
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