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Interleukin-10 (IL-10) is produced by many immune cells, such as T cells, macrophages, mast cells and dendritic cells. It is usually secreted as a homodimer and, upon binding to receptors, inhibits the synthesis of several cytokines, including IFN-gamma, IL-2, IL-3, TNF, and GM-CSF produced by activated macrophages and Th2 cells. It also displays the ability to suppress Antigen-Presenting Cell (APC) function.
Measured in a bioassay using C6 cells, the ED50 is < 8.0 μg /ml.
Protein Construction: IL-10 (Ser19-Asn178)
Accession#: P29456
Apparent Molecular Weight: 8~22 kDa, reducing conditions
Endotoxin < 0.2 EU/μg
Lyophilized after extensive dialysis against PBS.
| Form | Lyophilized powder |
| Solubility (25°C) | Reconstitute the lyophilized powder in ddH2O or PBS up to 100 μg/ml. |
| Storage | Stored at ≤ -20°C, stable for up to 6 months after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months. |
[5] P Lu, et al. J Interferon Cytokine Res. Cloning and expression of canine interleukin-10
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