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Didox

Cat. No. M8770

All AbMole products are for research use only, cannot be used for human consumption.

Didox Structure
Synonym:

N,3,4-Trihydroxybenzamide

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Quality Control & Documentation
Biological Activity

Didox is a ribonucleotide reductase (RNR) inhibitor that inhibits proliferation of and decreased secretion of cytokines IL-6, IFN-g, TNF-a, IL-2, IL-13, IL-10 and IL-4. Didox inhibits proliferation of tamoxifen-resistant breast cancer cells. Didox is an antioxidant that potentiates the cytotoxic profile of doxorubicin.

Chemical Information
Molecular Weight 169.13
Formula C7H7NO4
CAS Number 69839-83-4
Solubility (25°C) DMSO: 2 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Juliete A F Silva, et al. Didox (3,4-dihydroxybenzohydroxamic acid) reduces the vascular inflammation induced by acute intravascular hemolysis

[2] Michela Asperti, et al. The Antitumor Didox Acts as an Iron Chelator in Hepatocellular Carcinoma Cells

[3] Jamie Josephine Avila McLeod, et al. Didox (3,4-dihydroxybenzohydroxamic acid) suppresses IgE-mediated mast cell activation through attenuation of NFκB and AP-1 transcription

[4] Heather L Caslin, et al. Didox (3,4-dihydroxybenzohydroxamic acid) suppresses IL-33-induced cytokine production in primary mouse mast cells

[5] Ahmed M Al-Abd, et al. Didox potentiates the cytotoxic profile of doxorubicin and protects from its cardiotoxicity

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  Catalog
Abmole Inhibitor Catalog




Keywords: Didox, N,3,4-Trihydroxybenzamide supplier, inhibitors, activators

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