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Oclacitinib maleate

Cat. No. M5827
Oclacitinib maleate Structure
Synonym:

PF-03394197

Size Price Availability Quantity
5mg USD 74.7  USD83 In stock
10mg USD 108  USD120 In stock
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Quality Control
Biological Activity

Oclacitinib is a novel inhibitor of JAK family members with IC50 ranging from 10 to 99 nM and JAK1-dependent cytokines with IC50 ranging from 36 to 249 nM, which did not inhibit a panel of 38 non-JAK kinases.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 453.51
Formula C15H23N5O2S.C4H4O4
CAS Number 1640292-55-2
Purity 99.23%
Solubility 70 mg/mL in DMSO
Storage at -20°C
References

The pharmacokinetics of oclacitinib maleate, a Janus kinase inhibitor, in the dog.
Collard WT, et al. J Vet Pharmacol Ther. 2014 Jun;37(3):279-85. PMID: 24330031.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Oclacitinib maleate, PF-03394197 supplier, JAK, inhibitors

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