About 30 results found for searched term "JAK" (0.046 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M3735 | JAK2 Inhibitor V | JAK |
| NSC 42834, Z3 | ||
| JAK2 Inhibitor V, Z3 is a novel specific inhibitor of Jak2 which inhibits Jak2-V617F and Jak2-WT autophosphorylation in a dose-dependent manner but was not cytotoxic to cells at concentrations that inhibited kinase activity. | ||
| M3737 | Pyridone 6 | JAK |
| Merck-5, CMP 6, JAK Inhibitor I | ||
| Pyridone 6 is a potent, reversible, cell-permeable, and ATP-competitive inhibitor of JAK1 (IC50 = 15 nM for murine JAK1), JAK2 (IC50 = 1 nM), JAK3 (Ki = 5 nM), and Tyk 2 (IC50 = 1 nM) (Janus protein tyrosine kinases). | ||
| M9627 | JAK3-IN-6 (Compound 2) | JAK |
| JAK3-IN-2 | ||
| JAK3-IN-6 (Compound 2) CAS#: 1443235-95-7 is a potent and highly selective JAK3 inhibitor, with an IC50 of 0.15 nM. | ||
| M13789 | JAK2 JH2 Tracer | Fluorescent Dye |
| JAK2 JH2 Tracer is a fluorescent probe for the JAK2 JH2 domain, with Kd of 0.2 μM. | ||
| M28195 | JAK-IN-1 | JAK |
| JAK-IN-1 is a JAK1/2/3 inhibitor with IC50s of 0.26, 0.8 and 3.2 nM, respectively. JAK-IN-1 shows improved selectivity for JAK3 over JAK1. | ||
| M28334 | JAK-IN-3 | JAK |
| JAK-IN-3 (compound 22) is a potent JAK inhibitor, with IC50 values of 3 nM, 5 nM, 34 nM and 70 nM for JAK3, JAK1, TYK2 and JAK2, respectively. | ||
| M28893 | JAK3-IN-1 | JAK |
| JAK3-IN-1 is a potent, selective and orally active JAK3 inhibitor with an IC50 of 4.8 nM. JAK3-IN-1 shows over 180-fold more selective for JAK3 than JAK1 (IC50 of 896 nM) and JAK2 (IC50 of 1050 nM). | ||
| M41701 | JAK-IN-31 | JAK |
| JAK-IN-31 is a JAK inhibitor with IC50 ranges of ≤0.01µM, ≤0.01µM, 0.01-0.1 µM and ≤0.01µM for JAK1, JAK2, JAK3 and Tyk2 respectively. | ||
| M41702 | JAK-IN-27 | JAK |
| JAK-IN-27 is an orally active and potent JAKS family kinase inhibitor with IC50s of 3.0 nM (TYK2), 7.7 nM (JAK1), 629.6 nM (JAK3), respectively. | ||
| M41703 | JAK/HDAC-IN-3 | JAK |
| JAK/HDAC-IN-3 is a dual JAK and HDAC inhibitor, with IC50 values of 25.36 nM, 0.2 μM and 0.43 μM for JAK2, HDAC and HDAC1, respectively. | ||
| M41704 | JAK-IN-30 | JAK |
| JAK-IN-30 is a water-soluble JAK inhibitor with IC50 values of 2, 15, 18 and 2 nM for JAK2, JAK1, JAK3 and TYK2, respectively. | ||
| M41705 | JAK-IN-25 | JAK |
| JAK-IN-25 is a potent JAK inhibitor with IC50s of 6 nM, 21 nM, 8 nM, 1051 nM for TYK2, JAK1, JAK2, JAK3, respectively. | ||
| M41706 | JAK1-IN-10 | JAK |
| JAK1-IN-10, a cyano-substituted cyclic hydrazine derivative, is a potent and selective JAK1 inhibitor. | ||
| M41707 | JAK3-IN-14 | JAK |
| JAK3-IN-14 is a potent JAK3 inhibitor, with IC50 values of 38 and 600 nM for JAK3 and JAK2, respectively. | ||
| M41708 | JAK1-IN-11 | JAK |
| JAK1-IN-11 is a potent inhibitor of JAK, with IC50s of 0.02 nM (JAK1), and 0.44 nM (JAK2), respectively. | ||
| M41709 | JAK/HDAC-IN-2 | JAK |
| JAK/HDAC-IN-2 is a potent 2-amino-4-phenylaminopyrimidine JAK/HDAC dual-target inhibitor. | ||
| M41710 | JAK-IN-26 | JAK |
| JAK-IN-26 is an orally active JAK inhibitor with good pharmacokinetic characteristics. | ||
| M41712 | JAK1-IN-12 | JAK |
| JAK1-IN-12 is a selective inhibitor of JAK1, with IC50 of 0.0246 μM. | ||
| M41714 | JAK2-IN-9 | JAK |
| JAK2-IN-9 is a selective JAK2 inhibitor (IC50: 5 nM). | ||
| M41715 | JAK-STAT-IN-1 | JAK |
| JAK-STAT-IN-1 is a selective JAK-STAT inhibitor. | ||
| M41716 | JAK kinase-IN-1 | JAK |
| JAK kinase-IN-1 is a JAK inhibitor. | ||
| M41717 | JAK-IN-29 | JAK |
| JAK-IN-29 is a potent JAK inhibitor. | ||
| M41718 | JAK-IN-28 | JAK |
| JAK-IN-28 is a JAK inhibitor. | ||
| M43264 | Jak3tide | Others |
| Jak3tide (JAK3 Peptide substrate) is a biological active peptide. | ||
| M43806 | Londamocitinib | JAK |
| AZD4604; JAK1-IN-7 | ||
| Londamocitinib is a potent and selective JAK1 inhibitor with anti-inflammatory activity. | ||
| M49504 | JAK-2/3-IN-3 | Apoptosis |
| JAK-2-/3-IN-3 is a potent JAK2/3 inhibitor with IC50s of 13.00 and 14.86 nM for JAK2 and JAK3, respectively. | ||
| M49506 | HDAC/JAK/BRD4-IN-1 | Epigenetic Reader Domain |
| HDAC/JAK/BRD4-IN-1 is a potent HDAC/JAK/BRD4 triple inhibitor. | ||
| M49523 | Tubulin/JAK2-IN-1 | Microtubule |
| Tubulin/JAK2-IN-1 is a dual inhibitor of Janus kinase 2 (JAK2) and microtubule. | ||
| M49550 | JAK-IN-23 | JAK |
| JAK-IN-23 is an orally active double inhibitor of JAK/STAT and NF-κB. | ||
| M49551 | JAK-IN-5 hydrochloride | JAK |
| JAK-IN-5 hydrochloride is an inhibitor of JAK extracted from patent US20170121327A1, compound example 283. | ||
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