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 About 30 results found for searched term "JAK" (0.04 seconds)

Cat.No.  Name Target
M3735 JAK2 Inhibitor V JAK
NSC 42834, Z3
JAK2 Inhibitor V, Z3 is a novel specific inhibitor of Jak2 which inhibits Jak2-V617F and Jak2-WT autophosphorylation in a dose-dependent manner but was not cytotoxic to cells at concentrations that inhibited kinase activity.
M3737 Pyridone 6 JAK
Merck-5, CMP 6, JAK Inhibitor I
Pyridone 6 is a potent, reversible, cell-permeable, and ATP-competitive inhibitor of JAK1 (IC50 = 15 nM for murine JAK1), JAK2 (IC50 = 1 nM), JAK3 (Ki = 5 nM), and Tyk 2 (IC50 = 1 nM) (Janus protein tyrosine kinases).
M9627 JAK3-IN-6 (Compound 2) JAK
JAK3-IN-6 (Compound 2) CAS#: 1443235-95-7 is a potent and highly selective JAK3 inhibitor, with an IC50 of 0.15 nM.
M13789 JAK2 JH2 Tracer Fluorescent Dye
JAK2 JH2 Tracer is a fluorescent probe for the JAK2 JH2 domain, with Kd of 0.2 μM.
M28195 JAK-IN-1  JAK
JAK-IN-1 is a JAK1/2/3 inhibitor with IC50s of 0.26, 0.8 and 3.2 nM, respectively. JAK-IN-1 shows improved selectivity for JAK3 over JAK1.
M28334 JAK-IN-3  JAK
JAK-IN-3 (compound 22) is a potent JAK inhibitor, with IC50 values of 3 nM, 5 nM, 34 nM and 70 nM for JAK3, JAK1, TYK2 and JAK2, respectively.
M28893 JAK3-IN-1  JAK
JAK3-IN-1 is a potent, selective and orally active JAK3 inhibitor with an IC50 of 4.8 nM. JAK3-IN-1 shows over 180-fold more selective for JAK3 than JAK1 (IC50 of 896 nM) and JAK2 (IC50 of 1050 nM).
M41701 JAK-IN-31 JAK
JAK-IN-31 is a JAK inhibitor with IC50 ranges of ≤0.01µM, ≤0.01µM, 0.01-0.1 µM and ≤0.01µM for JAK1, JAK2, JAK3 and Tyk2 respectively.
M41702 JAK-IN-27 JAK
JAK-IN-27 is an orally active and potent JAKS family kinase inhibitor with IC50s of 3.0 nM (TYK2), 7.7 nM (JAK1), 629.6 nM (JAK3), respectively.
JAK/HDAC-IN-3 is a dual JAK and HDAC inhibitor, with IC50 values of 25.36 nM, 0.2 μM and 0.43 μM for JAK2, HDAC and HDAC1, respectively.
M41704 JAK-IN-30 JAK
JAK-IN-30 is a water-soluble JAK inhibitor with IC50 values of 2, 15, 18 and 2 nM for JAK2, JAK1, JAK3 and TYK2, respectively.
M41705 JAK-IN-25 JAK
JAK-IN-25 is a potent JAK inhibitor with IC50s of 6 nM, 21 nM, 8 nM, 1051 nM for TYK2, JAK1, JAK2, JAK3, respectively.
M41706 JAK1-IN-10 JAK
JAK1-IN-10, a cyano-substituted cyclic hydrazine derivative, is a potent and selective JAK1 inhibitor.
M41707 JAK3-IN-14 JAK
JAK3-IN-14 is a potent JAK3 inhibitor, with IC50 values of 38 and 600 nM for JAK3 and JAK2, respectively.
M41708 JAK1-IN-11 JAK
JAK1-IN-11 is a potent inhibitor of JAK, with IC50s of 0.02 nM (JAK1), and 0.44 nM (JAK2), respectively.
JAK/HDAC-IN-2 is a potent 2-amino-4-phenylaminopyrimidine JAK/HDAC dual-target inhibitor.
M41710 JAK-IN-26 JAK
JAK-IN-26 is an orally active JAK inhibitor with good pharmacokinetic characteristics.
M41712 JAK1-IN-12 JAK
JAK1-IN-12 is a selective inhibitor of JAK1, with IC50 of 0.0246 μM.
M41714 JAK2-IN-9 JAK
JAK2-IN-9 is a selective JAK2 inhibitor (IC50: 5 nM).
JAK-STAT-IN-1 is a selective JAK-STAT inhibitor.
M41716 JAK kinase-IN-1 JAK
JAK kinase-IN-1 is a JAK inhibitor.
M41717 JAK-IN-29 JAK
JAK-IN-29 is a potent JAK inhibitor.
M41718 JAK-IN-28 JAK
JAK-IN-28 is a JAK inhibitor.
M43264 Jak3tide Others
Jak3tide (JAK3 Peptide substrate) is a biological active peptide.
M43806 Londamocitinib JAK
AZD4604; JAK1-IN-7
Londamocitinib is a potent and selective JAK1 inhibitor with anti-inflammatory activity.
M49504 JAK-2/3-IN-3 Apoptosis
JAK-2-/3-IN-3 is a potent JAK2/3 inhibitor with IC50s of 13.00 and 14.86 nM for JAK2 and JAK3, respectively.
M49506 HDAC/JAK/BRD4-IN-1 Epigenetic Reader Domain
HDAC/JAK/BRD4-IN-1 is a potent HDAC/JAK/BRD4 triple inhibitor.
M49523 Tubulin/JAK2-IN-1 Microtubule
Tubulin/JAK2-IN-1 is a dual inhibitor of Janus kinase 2 (JAK2) and microtubule.
M49550 JAK-IN-23 JAK
JAK-IN-23 is an orally active double inhibitor of JAK/STAT and NF-κB.
M49551 JAK-IN-5 hydrochloride JAK
JAK-IN-5 hydrochloride is an inhibitor of JAK extracted from patent US20170121327A1, compound example 283.

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