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JAK3-IN-6 (Compound 2)

Cat. No. M9627
JAK3-IN-6 (Compound 2) Structure
Synonym:

JAK3-IN-2

Size Price Availability Quantity
10mg USD 136.8  USD152 In stock
50mg USD 410.4  USD456 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

JAK3-IN-6 (Compound 2) CAS#: 1443235-95-7 is a potent and highly selective JAK3 inhibitor, with an IC50 of 0.15 nM. JAK3-IN-6 (Compound 2) is 4300-fold selective for JAK3 over JAK1 in enzyme assays, 67-fold [interleukin (IL)-2 versus IL-6] or 140-fold [IL-2 versus erythropoietin or granulocyte-macrophage colony-stimulating factor (GMCSF)] selective in cellular reporter assays and >35-fold selective in human peripheral blood mononuclear cell assays (IL-7 versus IL-6 or GMCSF). In vivo, selective JAK3 inhibition was sufficient to block the development of inflammation in a rat model of rheumatoid arthritis, while sparing hematopoiesis.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 350.37
Formula C19H18N4O3
CAS Number 1443235-95-7
Purity >98%
Solubility DMSO ≥ 60 mg/mL
Storage at -20°C
References

Evaluation of JAK3 Biology in Autoimmune Disease Using a Highly Selective, Irreversible JAK3 Inhibitor
Fiona Elwood, et al. J Pharmacol Exp Ther. 2017 May;361(2):229-244. PMID: 28193636.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: JAK3-IN-6 (Compound 2), JAK3-IN-2 supplier, JAK, inhibitors

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