Free shipping on all orders over $ 500

JAK2 Inhibitor V

Cat. No. M3735
JAK2 Inhibitor V Structure
Synonym:

NSC 42834, Z3

Size Price Availability Quantity
5mg USD 216  USD240 In stock
10mg USD 360  USD400 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Z3 (NSC 42834) selectively inhibited Jak2 kinase function with no effect on Tyk2 or c-Src kinase function. Z3 significantly inhibited proliferation of the Jak2-V617F-expressing, human erythroleukemia cell line, HEL 92.1.7. The Z3-mediated reduction in cell proliferation correlated with reduced Jak2 and STAT3 tyrosine phosphorylation levels as well as marked cell cycle arrest. Finally, Z3 (NSC 42834) inhibited the growth of hematopoietic progenitor cells isolated from the bone marrow of an essential thrombocythemia patient harboring the Jak2-V617F mutation and a polycythemia vera patient carrying a Jak2-F537I mutation.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 344.45
Formula C23H24N2O
CAS Number 195371-52-9
Purity >98%
Solubility DMSO 40 mg/mL
Storage at -20°C
References

Prospect of JAK2 inhibitor therapy in myeloproliferative neoplasms.
Atallah E, et al. Expert Rev Anticancer Ther. 2009 May;9(5):663-70. PMID: 19445582.

Jak2 inhibitors: rationale and role as therapeutic agents in hematologic malignancies.
Sayyah J, et al. Curr Oncol Rep. 2009 Mar;11(2):117-24. PMID: 19216843.

Z3, a novel Jak2 tyrosine kinase small-molecule inhibitor that suppresses Jak2-mediated pathologic cell growth.
Sayyah J, et al. Mol Cancer Ther. 2008 Aug;7(8):2308-18. PMID: 18723478.

Related JAK Products
Delphinidin chloride

Delphinidin (chloride) is an anthocyanidin, a natural plant pigment which can modulate JAK/STAT3 and MAPKinase signaling to induce apoptosis in HCT116 cells.

AZD4205

AZD4205 is a novel potent and selective janus kinase 1 (JAK1) inhibitor, with IC50 value of 73 nM.

PF-06826647

PF-06826647, also known as Tyk2-IN-8, is a selective and orally administered tyrosine kinase 2 (TYK2) inhibitor, with IC50 of 17 nM.

PF-06700841 tosylate

PF-06700841 (Brepocitinib) tosylate is a dual inhibitor of JAK1 and TYK2, with IC50 values of 17 nM and 23 nM, respectively.

JAK3-IN-6 (Compound 2)

JAK3-IN-6 (Compound 2) CAS#: 1443235-95-7 is a potent and highly selective JAK3 inhibitor, with an IC50 of 0.15 nM.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: JAK2 Inhibitor V, NSC 42834, Z3 supplier, JAK, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.