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Recombinant Human TGF-α (E. coli)

Cat. No. M10430
Recombinant Human TGF-α (E. coli) Structure
Synonym:

Human Transforming Growth Factor-alpha

Size Price Availability Quantity
10ug USD 72  USD80 In stock
50ug USD 148.5  USD165 In stock
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Quality Control
  • Current batch:
  • Purity >95%, Endotoxin < 0.2 EU/μg
  • COA
  • MSDS
Biological Activity

Recombinant Human TGF-α, also known as sarcoma growth factor, TGF-type I and ETGF, is a member of the EGF family of cytokines. TGF-α signals through EGFR and acts synergistically with TGF-beta to promote the proliferation of a wide range of epidermal and epithelial cells. TGF-α is a transforming growth factor that is a ligand for the epidermal growth factor receptor, which activates a signaling pathway for cell proliferation, differentiation and development. This protein may act as either a transmembrane-bound ligand or a soluble ligand. The biological actions of TGF-α and EGF are similar. For instance, TGF-α and EGF bind to the same receptor. When TGF-α binds to EGFR it can initiate multiple cell proliferation events.

ED50 < 0.2ng/ml, measured by Cell Proliferation Assay using BALB/c 3T3 cells, corresponding to a specific activity of ≥ 5 x 106 units/mg.

Sequence: VVSHFNDCPD SHTQFCFHGT CRFLVQEDKP ACVCHSGYVG ARCEHADLLA

Lyophilized recombinant Human TGF-α remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, Human TGF-α should be stable up to 1 week at 4°C or up to 3 months at -20°C.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight
Formula
CAS Number
Purity >95%, Endotoxin < 0.2 EU/μg
Solubility Reconstituted in ddH2O or PBS at 100 μg/mL
Storage at -20°C
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Recombinant Human TGF-α (E. coli), Human Transforming Growth Factor-alpha supplier, Cytokines, inhibitors

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