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Resiquimod

Cat. No. M7189
Resiquimod Structure
Synonym:

R848; S28463

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
5mg USD 33  USD33 In stock
10mg USD 50  USD50 In stock
25mg USD 88  USD88 In stock
50mg USD 130  USD130 In stock
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Quality Control & Documentation
Biological Activity

Resiquimod is a agonist of Toll-like receptors 7 and 8 (TLR7/TLR8) that induces upregulation of cytokines such as TNF-α, IL-6 and IFN-α.

Chemical Information
Molecular Weight 314.38
Formula C17H22N4O2
CAS Number 144875-48-9
Solubility (25°C) DMSO 30 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Calcutt, et al. Br J Pharmacol. Zolantidine (SK&F 95282) is a potent selective brain penetrating histamine H2-receptor antagonist.

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Keywords: Resiquimod, R848; S28463 supplier, TLR, inhibitors, activators


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