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Trofinetide (NNZ-2566) acetate is a novel analogue of the amino-terminal tripeptide of IGF-1, stimulates synaptic maturation, inhibits the production of inflammatory cytokines and the hyperactivation of microglia and astrocytes, and increases the amount of available IGF-1 that can bind to the IGF-1 receptor. Trofinetide (NNZ-2566) has been shown to have neuroprotective effects in animal models of brain injury.
Sequence: G-α-Me-Pro-E.
| Molecular Weight | 375.36 |
| Formula | C15H25N3O8 |
| CAS Number | 853400-76-7 (free base) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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