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Trofinetide acetate

Cat. No. M21112
Trofinetide acetate Structure
Synonym:

NNZ-2566 acetate

Size Price Availability Quantity
5mg USD 390  USD390 In stock
10mg USD 580  USD580 In stock
50mg USD 1740  USD1740 In stock
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Quality Control & Documentation
Biological Activity

Trofinetide (NNZ-2566) acetate is a novel analogue of the amino-terminal tripeptide of IGF-1, stimulates synaptic maturation, inhibits the production of inflammatory cytokines and the hyperactivation of microglia and astrocytes, and increases the amount of available IGF-1 that can bind to the IGF-1 receptor. Trofinetide (NNZ-2566) has been shown to have neuroprotective effects in animal models of brain injury.

Sequence: G-α-Me-Pro-E.

Chemical Information
Molecular Weight 375.36
Formula C15H25N3O8
CAS Number 853400-76-7 (free base)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Mona Darwish, et al. Clin Drug Investig. A Phase 1, Open-Label Study to Evaluate the Effects of Food and Evening Dosing on the Pharmacokinetics of Oral Trofinetide in Healthy Adult Subjects

[2] Jeffrey L Neul, et al. Contemp Clin Trials. Design and outcome measures of LAVENDER, a phase 3 study of trofinetide for Rett syndrome

[3] Ramkumar Aishworiya, et al. Neurotherapeutics. An Update on Psychopharmacological Treatment of Autism Spectrum Disorder

[4] Elizabeth Berry-Kravis, et al. Pediatr Neurol. A Double-Blind, Randomized, Placebo-Controlled Clinical Study of Trofinetide in the Treatment of Fragile X Syndrome

[5] Daniel G Glaze, et al. Neurology. Double-blind, randomized, placebo-controlled study of trofinetide in pediatric Rett syndrome

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Keywords: Trofinetide acetate, NNZ-2566 acetate supplier, Peptides, inhibitors, activators


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