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Dihydrocytochalasin B is a Cytokinesis inhibitor and changes the morphology of the cells, similar to that of cytochalasin B. Dihydrocytochalasin B does not inhibit glucose transport. Dihydrocytochalasin B inhibits active calcium transport and causes a Ca2+increase in the mucosal scrapings. Dihydrocytochalasin B disrupts the actin structure and inhibits the ability of growth factors to stimulate DNA synthesis, reversibly blocks initiation of DNA synthesis.
| Molecular Weight | 481.62 |
| Formula | C29H39NO5 |
| CAS Number | 39156-67-7 |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Actin-Related Protein Products |
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| EG-011
EG-011 is a first-in-class, potent Wiskott-Aldrich Syndrome Protein (WASP) activator that activates the self-inhibited form of WASP via strong actin polymerization.In addition, EG-011 has selective anti-lymphoma activity. |
| Cytochalasin B
Cytochalasin B is a cell-permeable mycotoxin binding to the barbed end of actin filaments, disrupting the formation of actin polymers, with Kd value of 1.4-2.2 nM for F-actin. |
| Jasplakinolide
Jasplakinolide is an actin-specific reagent that promotes actin polymerization and stabilizes actin filaments. Jasplakinolide binds to F-actin competitively with phalloidin with a Kd of 15 nM. Jasplakinolide, a naturally occurring cyclic peptide from the marine sponge, has both fungicidal and anti-cancer activity. |
| Cytochalasin D
Cytochalasin D (Zygosporin A) is a cytopermeable actin polymerization inhibitor derived from fungi, which inhibits g-actin -- Cofilin interaction by binding g-actin. Cytochalasin D can also inhibit the binding of Cofilin to F-actin, reduce the release of exosomes and induce YAP phosphorylation. |
| SMIFH2
SMIFH2 is a fH2 domain inhibitor; prevents actin nucleation. |
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Products are for research use only. Not for human use. We do not sell to patients.
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