All AbMole products are for research use only, cannot be used for human consumption.
Cytochalasin D (Zygosporin A) is a cytopermeable actin polymerization inhibitor derived from fungi, which inhibits g-actin -- Cofilin interaction by binding g-actin. Cytochalasin D (Zygosporin A) can also inhibit the binding of Cofilin to F-actin, reduce the release of exosomes and induce YAP phosphorylation. Cytochalasin D is a potent inhibitor of actin polymerization. Cytochalasin D disrupts actin microfilaments. Cytochalasin D activates the p53-dependent pathways. Cytochalasin D inhibits smooth muscle contraction. Cytochalasin D inhibits insulin-stimulated glucose transport.
| Molecular Weight | 507.62 |
| Formula | C30H37NO6 |
| CAS Number | 22144-77-0 |
| Solubility (25°C) | DMSO 20 mg/mL |
| Storage | Powder -20°C |
[1] Gabor Erdoes, et al. The Dark Side of FIBTEM: Cytochalasin D
[5] R K Chiang, et al. Cytochalasin D reversibly weakens retinal adhesiveness
| Related Actin-Related Protein Products |
|---|
| EG-011
EG-011 is a first-in-class, potent Wiskott-Aldrich Syndrome Protein (WASP) activator that activates the self-inhibited form of WASP via strong actin polymerization.In addition, EG-011 has selective anti-lymphoma activity. |
| Dihydrocytochalasin B
Dihydrocytochalasin B is a Cytokinesis inhibitor and changes the morphology of the cells, similar to that of cytochalasin B. |
| Cytochalasin B
Cytochalasin B is a cell-permeable mycotoxin binding to the barbed end of actin filaments, disrupting the formation of actin polymers, with Kd value of 1.4-2.2 nM for F-actin. |
| Jasplakinolide
Jasplakinolide is an actin-specific reagent that promotes actin polymerization and stabilizes actin filaments. Jasplakinolide binds to F-actin competitively with phalloidin with a Kd of 15 nM. Jasplakinolide, a naturally occurring cyclic peptide from the marine sponge, has both fungicidal and anti-cancer activity. |
| SMIFH2
SMIFH2 is a fH2 domain inhibitor; prevents actin nucleation. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.
