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Cytochalasin B

Cat. No. M9203

All AbMole products are for research use only, cannot be used for human consumption.

Cytochalasin B Structure
Synonym:

Phomin

Size Price Availability Quantity
1mg USD 105  USD105 In stock
5mg USD 440  USD440 In stock
10mg USD 800  USD800 In stock
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Quality Control & Documentation
Biological Activity

Cytochalasin B is a cell-permeable mycotoxin binding to the barbed end of actin filaments, inhibits the enlongation and shortening of actin filaments, with Kds of 2.2 nM and 1.4 nM for F-actin in the presence of MgCl2 (2 mM) or MgCl2 (2 mM) plus KCl, respectively. Cytochalasin B (6 μM) increases the myofibrillar fragmentation index (MFI), which is attributed to the intensely breaking of myofibrillar proteins into short segments. Cytochalasin B also accelerates the disruption of actin filaments.

In vivo, Cytochalasin B (10, 25, 50 mg/kg, i.p.) dose-dependently increases the life expectancy of Balb/c mice bearing with P388/ADR leukemias. Cytochalasin B at 50 mg/kg produces 10 % long-term survival in the multidrug resistant P388/ADR cohort, and 40 % long-term survival in the drug sensitive P388/S cohort.

Product Citations
Chemical Information
Molecular Weight 479.61
Formula C29H37NO5
CAS Number 14930-96-2
Form Solid
Solubility (25°C) DMSO 10 mM
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Zhou C, et al. Food Res Int. The effect of Cytochalasin B and Jasplakinolide on depolymerization of actin filaments in goose muscles during postmortem conditioning.

[2] Theodoropoulos PA, et al. Biochem Pharmacol. Cytochalasin B may shorten actin filaments by a mechanism independent of barbed end capping.

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Dihydrocytochalasin B

Dihydrocytochalasin B is a Cytokinesis inhibitor and changes the morphology of the cells, similar to that of cytochalasin B.

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SMIFH2

SMIFH2 is a fH2 domain inhibitor; prevents actin nucleation.

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Keywords: Cytochalasin B, Phomin supplier, Actin-Related Protein, inhibitors, activators

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