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S1P Receptor S1P Receptor

Cat.No.  Name Information
M1712 FTY720 hydrochloride Fingolimod (FTY720) HCl is a 1-phospho-neuraminol S1P receptor antagonist with an IC50 of 0.33 nM. , FTY720 can dephosphorylate AMPK by activating PP2A and reduce the expression level of phosphorylated eEF2K, ultimately leading to ADCD and iron death in human multiple myeloma cells.
M9383 Opaganib (ABC294640) Opaganib (ABC294640) is a selective and competitive SK2 inhibitor with a Ki of 9.8 μM.
M14000 Fingolimod Fingolimod (FTY720 free base) is a sphingosine 1-phosphate (S1P) antagonist with an IC50 of 0.033 nM in K562 and NK cells. Fingolimod also is a pak1 activator, a immunosuppressant.
M2428 BAF312 BAF312 (Siponimod) is a next-generation S1P receptor modulator, selective for S1P1 and S1P5 receptors with EC50 of 0.39 nM and 0.98 nM, exhibits >1000-fold selectivity over S1P2, S1P3 and S1P4 receptors.
M3129 W146 W146 is a potent S1P1 selective antagonist with Ki of 18 nM.
M3012 SKI II SKI II is a highly selective and non ATP-competitive S1P receptor inhibitor with IC50 of 0.5 μM, while exhibits no inhibitory on other kinases including PI3K, PKCα and ERK2.
M2797 KRP-203 hydrochloride Mocravimod (KRP-203) hydrochloride is a potent, orally active sphingosine receptor S1P1 and S1P4 agonist with EC50s of 1 nM and 10 nM, respectively, and may be used in studies related to ulcerative colitis (UC).
M2787 JTE 013 JTE 013 is a potent and selective S1P2 antagonist with IC50 of 17.6 nM.
M2546 CYM-5442 CYM-5442 is a potent and selective S1P1 agonist with EC50 of 1.35 nM.
M2476 SEW 2871 SEW 2871 is a cell-permeable, selective S1P1 receptor agonist.
M40974 VTX-002 VTX-002 is an orally active, selective S1P receptor 1 modulator for studies related to ulcerative colitis.
M31389 TRV045 TRV045 is an S1P receptor modulator that can be used in studies related to central nervous system disorders.
M28175 S1P1 agonist III  S1P1 Agonist III is a potent and orally active S1P1 agonist with EC50 of 18 nM; no activity on S1P3.
M28144 RP101075  RP101075, an active metabolite of Ozanimod, is a potent, orally active S1PR (sphingosine-1-phosphate receptor 1) agonist, with an EC50 of 0.27 nM. RP101075 displays >100-fold selectivity over S1PR5 (EC50=5.9 nM) and >10000-fold over S1PR 2, 3, and 4. RP101075 displays superior cardiovascular safety profile.
M24539 Sonepcizumab Sonepcizumab (LT 1009) is a fully humanized anti-S1P monoclonal antibody. Sonepcizumab has the potential for the research of metastatic renal cell carcinoma (mRCC).
M21193 SAR247799 The S1P1 agonist SAR247799 is a biased agonist of the S1P1 sphingosine receptor, preferentially activating G protein signaling over the β-arrestin and internalization pathways.
M14001 FTY720 (S)-Phosphate FTY720 (S)-Phosphate is an agonist of S1P receptor 1 (S1PR1), used in the research of acute inflammatory diseases such as acute lung injury.
M13998 ASP-4058 ASP-4058 is a next-generation, selective and oral bioactive agonist for Sphingosine 1-Phosphate receptors 1 and 5 (S1P1 and S1P5), ameliorates rodent experimental autoimmune encephalomyelitis with a favorable safety profile.
M8646 A-971432 A-971432 is an orally bioavailable, non-clastogenic, azetidinecarboxylate compound that acts as a highly potent and selective sphingosine-1-phosphate receptor 5 agonist (IC50 = 6 nM/S1P5, 362 nM/S1P1 and >10 μM/S1P3 in a radio-ligand binding assay).
M8611 Ex26 Ex26 is a peripherally-restricted biphenylcarboxamide derivative that acts as a highly potent and subtype-selective S1P1 antagonist (IC50 = 0.93 nM against S1PR1 and >3.1 μM against S1PR2/3/4/5).
M7465 VPC 23019 VPC 23019 is a s1P1 and S1P3 antagonist.
M7398 TC-SP 14 TC-SP 14 is a potent S1P1 receptor agonist.
M7214 RP 001 hydrochloride RP 001 hydrochloride is a potent S1P1 agonist.
M6642 CYM 50260 CYM 50260 is a potent and selective S1P4 agonist.




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