Cat.No. | Name | Information |
---|---|---|
M1712 | FTY720 hydrochloride | Fingolimod (FTY720) HCl is a 1-phospho-neuraminol S1P receptor antagonist with an IC50 of 0.33 nM. , FTY720 can dephosphorylate AMPK by activating PP2A and reduce the expression level of phosphorylated eEF2K, ultimately leading to ADCD and iron death in human multiple myeloma cells. |
M9383 | Opaganib (ABC294640) | Opaganib (ABC294640) is a selective and competitive SK2 inhibitor with a Ki of 9.8 μM. |
M14000 | Fingolimod | Fingolimod (FTY720 free base) is a sphingosine 1-phosphate (S1P) antagonist with an IC50 of 0.033 nM in K562 and NK cells. Fingolimod also is a pak1 activator, a immunosuppressant. |
M2428 | BAF312 | BAF312 (Siponimod) is a next-generation S1P receptor modulator, selective for S1P1 and S1P5 receptors with EC50 of 0.39 nM and 0.98 nM, exhibits >1000-fold selectivity over S1P2, S1P3 and S1P4 receptors. |
M3129 | W146 | W146 is a potent S1P1 selective antagonist with Ki of 18 nM. |
M3012 | SKI II | SKI II is a highly selective and non ATP-competitive S1P receptor inhibitor with IC50 of 0.5 μM, while exhibits no inhibitory on other kinases including PI3K, PKCα and ERK2. |
M2797 | KRP-203 hydrochloride | Mocravimod (KRP-203) hydrochloride is a potent, orally active sphingosine receptor S1P1 and S1P4 agonist with EC50s of 1 nM and 10 nM, respectively, and may be used in studies related to ulcerative colitis (UC). |
M2787 | JTE 013 | JTE 013 is a potent and selective S1P2 antagonist with IC50 of 17.6 nM. |
M2546 | CYM-5442 | CYM-5442 is a potent and selective S1P1 agonist with EC50 of 1.35 nM. |
M2476 | SEW 2871 | SEW 2871 is a cell-permeable, selective S1P1 receptor agonist. |
M40974 | VTX-002 | VTX-002 is an orally active, selective S1P receptor 1 modulator for studies related to ulcerative colitis. |
M31389 | TRV045 | TRV045 is an S1P receptor modulator that can be used in studies related to central nervous system disorders. |
M28175 | S1P1 agonist III | S1P1 Agonist III is a potent and orally active S1P1 agonist with EC50 of 18 nM; no activity on S1P3. |
M28144 | RP101075 | RP101075, an active metabolite of Ozanimod, is a potent, orally active S1PR (sphingosine-1-phosphate receptor 1) agonist, with an EC50 of 0.27 nM. RP101075 displays >100-fold selectivity over S1PR5 (EC50=5.9 nM) and >10000-fold over S1PR 2, 3, and 4. RP101075 displays superior cardiovascular safety profile. |
M24539 | Sonepcizumab | Sonepcizumab (LT 1009) is a fully humanized anti-S1P monoclonal antibody. Sonepcizumab has the potential for the research of metastatic renal cell carcinoma (mRCC). |
M21193 | SAR247799 | The S1P1 agonist SAR247799 is a biased agonist of the S1P1 sphingosine receptor, preferentially activating G protein signaling over the β-arrestin and internalization pathways. |
M14001 | FTY720 (S)-Phosphate | FTY720 (S)-Phosphate is an agonist of S1P receptor 1 (S1PR1), used in the research of acute inflammatory diseases such as acute lung injury. |
M13998 | ASP-4058 | ASP-4058 is a next-generation, selective and oral bioactive agonist for Sphingosine 1-Phosphate receptors 1 and 5 (S1P1 and S1P5), ameliorates rodent experimental autoimmune encephalomyelitis with a favorable safety profile. |
M8646 | A-971432 | A-971432 is an orally bioavailable, non-clastogenic, azetidinecarboxylate compound that acts as a highly potent and selective sphingosine-1-phosphate receptor 5 agonist (IC50 = 6 nM/S1P5, 362 nM/S1P1 and >10 μM/S1P3 in a radio-ligand binding assay). |
M8611 | Ex26 | Ex26 is a peripherally-restricted biphenylcarboxamide derivative that acts as a highly potent and subtype-selective S1P1 antagonist (IC50 = 0.93 nM against S1PR1 and >3.1 μM against S1PR2/3/4/5). |
M7465 | VPC 23019 | VPC 23019 is a s1P1 and S1P3 antagonist. |
M7398 | TC-SP 14 | TC-SP 14 is a potent S1P1 receptor agonist. |
M7214 | RP 001 hydrochloride | RP 001 hydrochloride is a potent S1P1 agonist. |
M6642 | CYM 50260 | CYM 50260 is a potent and selective S1P4 agonist. |
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