| Cat.No. | Name | Information |
|---|---|---|
| M1712 | FTY720 hydrochloride | Fingolimod (FTY720) HCl is a 1-phospho-neuraminol S1P receptor antagonist with an IC50 of 0.33 nM. , FTY720 can dephosphorylate AMPK by activating PP2A and reduce the expression level of phosphorylated eEF2K, ultimately leading to ADCD and iron death in human multiple myeloma cells. |
| M9383 | Opaganib | Opaganib (ABC294640) is a selective and competitive SK2 inhibitor with a Ki of 9.8 μM. |
| M14000 | Fingolimod | Fingolimod (FTY720 free base) is a sphingosine 1-phosphate (S1P) antagonist with an IC50 of 0.033 nM in K562 and NK cells. Fingolimod also is a pak1 activator, a immunosuppressant. |
| M2428 | BAF312 | BAF312 (Siponimod) is a next-generation S1P receptor modulator, selective for S1P1 and S1P5 receptors with EC50 of 0.39 nM and 0.98 nM, exhibits >1000-fold selectivity over S1P2, S1P3 and S1P4 receptors. |
| M2797 | KRP-203 hydrochloride | Mocravimod (KRP-203) hydrochloride is a potent, orally active sphingosine receptor S1P1 and S1P4 agonist with EC50s of 1 nM and 10 nM, respectively, and may be used in studies related to ulcerative colitis (UC). |
| M2546 | CYM-5442 | CYM-5442 is a potent and selective S1P1 agonist with EC50 of 1.35 nM. CYM5442 activates S1P1-dependent p42/p44-MAPK phosphorylation. CYM5442 can easily penetrate the central nervous system (CNS). |
| M6275 | PF 429242 | PF-429242 efficiently prevented the processing of GPC from the prototypic arenavirus lymphocytic choriomeningitis virus (LCMV) and LASV, which correlated with the compound's potent antiviral activity against LCMV and LASV in cultured cells. |
| M5886 | Ponesimod | Ponesimod(ACT-128800) is an orally active, selective sphingosine-1-phosphate receptor 1 (S1P1) immunomodulator with EC50 of 5.7 nM. |
| M5244 | Ozanimod | Ozanimod (RPC1063) is a selective, orally active sphingosine-1-phosphate (S1P) receptor modulator that binds to S1PR1 and S1PR5, and can be used in studies related to ulcerative colitis (UC). |
| M3129 | W146 | W146 is a potent S1P1 selective antagonist with Ki of 18 nM. |
| M3012 | SKI II | SKI II is a highly selective and non ATP-competitive S1P receptor inhibitor with IC50 of 0.5 μM, while exhibits no inhibitory on other kinases including PI3K, PKCα and ERK2. |
| M2787 | JTE 013 | JTE 013 is a potent and selective S1P2 antagonist with IC50 of 17.6 nM. |
| M2546 | CYM-5442 | CYM-5442 is a potent and selective S1P1 agonist with EC50 of 1.35 nM. CYM5442 activates S1P1-dependent p42/p44-MAPK phosphorylation. CYM5442 can easily penetrate the central nervous system (CNS). |
| M2476 | SEW2871 | SEW2871 is an orally active, potent, highly selective S1P1 (sphingosine-1-phosphate type 1 receptor) agonist, with an EC50 of 13.8 nM. SEW2871 activates ERK, Akt, and Rac signaling pathways and induces S1P1 internalization and recycling. |
| M40974 | VTX-002 | VTX-002 is an orally active, selective S1P receptor 1 modulator for studies related to ulcerative colitis. |
| M31389 | TRV045 | TRV045 is an S1P receptor modulator that can be used in studies related to central nervous system disorders. |
| M28175 | S1P1 agonist III | S1P1 Agonist III is a potent and orally active S1P1 agonist with EC50 of 18 nM; no activity on S1P3. |
| M28144 | RP101075 | RP101075, an active metabolite of Ozanimod, is a potent, orally active S1PR (sphingosine-1-phosphate receptor 1) agonist, with an EC50 of 0.27 nM. RP101075 displays >100-fold selectivity over S1PR5 (EC50=5.9 nM) and >10000-fold over S1PR 2, 3, and 4. RP101075 displays superior cardiovascular safety profile. |
| M21193 | SAR247799 | The S1P1 agonist SAR247799 is a biased agonist of the S1P1 sphingosine receptor, preferentially activating G protein signaling over the β-arrestin and internalization pathways. |
| M14001 | FTY720 (S)-Phosphate | FTY720 (S)-Phosphate is an agonist of S1P receptor 1 (S1PR1), used in the research of acute inflammatory diseases such as acute lung injury. |
| M8646 | A-971432 | A-971432 is an orally bioavailable, non-clastogenic, azetidinecarboxylate compound that acts as a highly potent and selective sphingosine-1-phosphate receptor 5 agonist (IC50 = 6 nM/S1P5, 362 nM/S1P1 and >10 μM/S1P3 in a radio-ligand binding assay). |
| M8611 | Ex26 | Ex26 is a peripherally-restricted biphenylcarboxamide derivative that acts as a highly potent and subtype-selective S1P1 antagonist (IC50 = 0.93 nM against S1PR1 and >3.1 μM against S1PR2/3/4/5). |
| M7465 | VPC 23019 | VPC 23019 is a s1P1 and S1P3 antagonist. |
| M7398 | TC-SP 14 | TC-SP 14 is a potent S1P1 receptor agonist. |
| M7214 | RP 001 hydrochloride | RP 001 hydrochloride is a potent S1P1 agonist. |
| M6642 | CYM 50260 | CYM 50260 is a potent and selective S1P4 agonist. |
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