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Opaganib (ABC294640) is a selective and competitive SK2 inhibitor with a Ki of 9.8 μM.
Cell Death Discov. 2023 Jan 18;9(1):12.
Nuclear SPHK2/S1P induces oxidative stress and NLRP3 inflammasome activation via promoting p53 acetylation in lipopolysaccharide-induced acute lung injury
Opaganib purchased from AbMole
| Molecular Weight | 380.91 |
| Formula | C23H25ClN2O |
| CAS Number | 915385-81-8 |
| Solubility (25°C) | DMSO ≥ 10 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Luca Pagani, et al. Next questions in Molecular Anthropology
[2] Francis D Pagani. Invited Commentary
[3] Eduardo Pagani. Why are biosimilars much more complex than generics?
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