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VPC 23019

Cat. No. M7465
VPC 23019 Structure
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

VPC 23019 is a sphingosine-1-phosphate receptor antagonist. VPC 23019 inhibits S1P1 and S1P3 receptors (pKi values are 7.86 and 5.93 respectively).

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 372.4
Formula C17H29N2O5P
CAS Number 449173-19-7
Purity >98%
Solubility 2eq. NaOH 18.62 mg/mL
Storage at -20°C
References

Bradykinin receptors and their antagonists.
Regoli, et al. Eur J Pharmacol. 1998;348: 1. PMID: 9650825.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: VPC 23019 supplier, S1P Receptor, inhibitors

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