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Cat. No. M2428
BAF312 Structure


Size Price Availability Quantity
5mg USD 81  USD90 In stock
10mg USD 121.5  USD135 In stock
50mg USD 405  USD450 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

BAF312 (Siponimod) is a next-generation S1P receptor modulator, selective for S1P1 and S1P5 receptors with EC50 of 0.39 nM and 0.98 nM, exhibits >1000-fold selectivity over S1P2, S1P3 and S1P4 receptors.

Cell Experiment
Cell lines CHO cells
Preparation method Agonist-mediated internalization of S1P1 receptors in CHO cells analysed by flow cytometry
Myc-tag hS1P1 cells were incubated for 1 h with agonist at 37°C in standard culture medium followed by a PBS wash. An aliquot was kept on ice for 3 h, while another aliquot was left for 3 (or 12) h in culture medium (no agonist) at 37°C. The cells were then incubated either with 4 µg·mL−1 monoclonal mouse anti C-myc IgG1 (Roche Applied Science, Mannheim, Germany) antibody or with isotype control mouse IgG1 (Pharmingen, BD Biosciences, Basel, Switzerland) for 60 min at 4°C, followed by an incubation with 1 µg·mL−1 of Alexa488-labelled goat anti-mouse secondary conjugates (Molecular Probes, Juro Supply, Luzern, Switzerland). The cells were subjected to flow cytometry measurements using 10000 viable cells per sample.
Concentrations 1 μM
Incubation time 1h
Animal Experiment
Animal models EAE model in the DA rat
Formulation 1% aqueous carboxy-methylcellulose (C-4888, Sigma Chemical Co, St Louis, MO)
Dosages 0.03, 0.3 and 3 mg/kg once daily
Administration oral gavage
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 516.6
Formula C29H35F3N2O3
CAS Number 1230487-00-9
Purity >98%
Solubility DMSO 10 mM
Storage at -20°C

The selective sphingosine 1-phosphate receptor modulator BAF312 redirects lymphocyte distribution and has species-specific effects on heart rate.
Gergely P, et al. Br J Pharmacol. 2012 Nov;167(5):1035-47. PMID: 22646698.

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Abmole Inhibitor Catalog 2017

Keywords: BAF312, Siponimod supplier, S1P Receptor, inhibitors

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