SEW 2871 is a novel, potent and selective sphingosine-1-phosphate 1 (S1P1) receptor agonist. SEW 2871 activates S1P1 receptor with an EC50 of 13 nM, but does not activate S1P2, S1P3, S1P4 or S1P5 receptors at concentrations up to 10 μM. SEW 2871 is cell-permeable and active in vivo.
| Molecular Weight | 440.36 |
| Formula | C20H10F6N2OS |
| CAS Number | 256414-75-2 |
| Form | Solid |
| Solubility (25°C) | DMSO 8 mg/mL |
| Storage | 2-8°C |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[2] Dongdong Zhang, et al. The S1PR1 agonist SEW2871 promotes the survival of skin flap
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