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JTE 013

Cat. No. M2787
JTE 013 Structure
Size Price Availability Quantity
5mg USD 72  USD80 In stock
10mg USD 99  USD110 In stock
25mg USD 216  USD240 In stock
50mg USD 396  USD440 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

JTE 013 is a potent and selective S1P2 antagonist with IC50 of 17.6 nM.

Customer Product Validations & Biological Datas
Source J Neurophysiol (2012). Figure 1. JTE 013
Method RT-PCR
Cell Lines sensory neurons
Concentrations 100 nM
Incubation Time 15-min
Results The number of APs at each time point was then normalized to the respective control values, and this analysis demonstrated that JTE-013 produced a rapid and significant increase in excitability in 70% of the sensory neurons compared with their control values
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 408.29
Formula C17H19Cl2N7O
CAS Number 383150-41-2
Purity >98%
Solubility DMSO 60 mg/mL
Storage at -20°C
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: JTE 013 supplier, S1P Receptor, inhibitors

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