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KRP-203 hydrochloride

Cat. No. M2797
KRP-203 hydrochloride Structure
Synonym:

Mocravimod

Size Price Availability Quantity
1mg USD 108  USD120 In stock
2mg USD 162  USD180 In stock
5mg USD 252  USD280 In stock
10mg USD 405  USD450 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Mocravimod (KRP-203) hydrochloride is a S1P1 and S1P4 receptors agonist with EC50 of 1 nM and 10 nM, respectively.

Customer Product Validations & Biological Datas
Source Arterioscler Thromb Vasc Biol (2013). Figure 3. KRP-203
Method i.v.
Cell Lines LDL-R-/- mice
Concentrations 3.0 mg/kg
Incubation Time 16 weeks
Results In addition, reduced production of interleukin (IL)-2 and interferon (IFN)-γ, 2 cytokines released from activated CD4+ T cells in response to concanavalin A or phytohaemagglutinin, was noted in splenocytes obtained from KRP-203–treated mice
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 480.45
Formula C24H26ClNO3S.HCl
CAS Number 509088-69-1
Purity >98%
Solubility DMSO 10 mM
Storage at -20°C
References

KRP-203, a novel synthetic immunosuppressant, prolongs graft survival and attenuates chronic rejection in rat skin and heart allografts
Hisashi Shimizu, et al. Circulation. 2005 Jan 18;111(2):222-9. PMID: 15642767.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: KRP-203 hydrochloride, Mocravimod supplier, S1P Receptor, inhibitors

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