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CYM 50260

Cat. No. M6642
CYM 50260 Structure
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

CYM 50260 is a potent sphingosine-1-phosphate receptor 4 (S1P4) agonist (EC50 = 45 nM). Displays no activity at other S1P receptor subtypes (S1P1-3 and S1P5) at concentrations up to 25 μM.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 350.6
Formula C14H11Cl3FNO2
CAS Number 1355026-60-6
Purity >98%
Solubility DMSO 35.06 mg/mL
Storage at -20°C
References

Discovery of potent, orally available vanilloid receptor-1 antagonists Structure-activity relationship of N-aryl cinnamides.
Doherty, et al. J Med Chem. 2005;48: 71. PMID: 15634002.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: CYM 50260 supplier, S1P Receptor, inhibitors

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