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FTY720 (S)-Phosphate

Cat. No. M14001
FTY720 (S)-Phosphate Structure
Synonym:

(S)-FTY720P; (S)-FTY720 phosphate

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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

FTY720 (S)-Phosphate is an agonist of S1P receptor 1 (S1PR1), used in the research of acute inflammatory diseases such as acute lung injury.

<span style='color:#ff0000;'><strong>*The compound is unstable in solutions, freshly prepared is recommended</strong></span>


Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 387.45
Formula
CAS Number 402616-26-6
Purity >99%
Solubility
Storage at -20°C
References

[1] Ilaria Callegari, et al. Update on treatment in multiple sclerosis

[2] Reshmi Roy, et al. Sphingosine 1-Phosphate Receptor Modulators for Multiple Sclerosis

[3] Anja Nitzsche, et al. Endothelial S1P 1 Signaling Counteracts Infarct Expansion in Ischemic Stroke

[4] Hideru Obinata, et al. Sphingosine 1-phosphate and inflammation

[5] Lichun Wang, et al. FTY720 (s)-phosphonate preserves sphingosine 1-phosphate receptor 1 expression and exhibits superior barrier protection to FTY720 in acute lung injury

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Keywords: FTY720 (S)-Phosphate, (S)-FTY720P; (S)-FTY720 phosphate supplier, LPL Receptor, inhibitors

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