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FTY720 (S)-Phosphate

Cat. No. M14001
FTY720 (S)-Phosphate Structure
Synonym:

(S)-FTY720P; (S)-FTY720 phosphate

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Biological Activity

FTY720 (S)-Phosphate is an agonist of S1P receptor 1 (S1PR1), used in the research of acute inflammatory diseases such as acute lung injury.

<span style='color:#ff0000;'><strong>*The compound is unstable in solutions, freshly prepared is recommended</strong></span>


Chemical Information
Molecular Weight 387.45
CAS Number 402616-26-6
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Ilaria Callegari, et al. Update on treatment in multiple sclerosis

[2] Reshmi Roy, et al. Sphingosine 1-Phosphate Receptor Modulators for Multiple Sclerosis

[3] Anja Nitzsche, et al. Endothelial S1P 1 Signaling Counteracts Infarct Expansion in Ischemic Stroke

[4] Hideru Obinata, et al. Sphingosine 1-phosphate and inflammation

[5] Lichun Wang, et al. FTY720 (s)-phosphonate preserves sphingosine 1-phosphate receptor 1 expression and exhibits superior barrier protection to FTY720 in acute lung injury

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Keywords: FTY720 (S)-Phosphate, (S)-FTY720P; (S)-FTY720 phosphate supplier, LPL Receptor, inhibitors, activators

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