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SKI II

Cat. No. M3012
SKI II Structure
Synonym:

SphK-I2

Size Price Availability Quantity
10mg USD 61.2  USD68 In stock
25mg USD 126  USD140 In stock
50mg USD 216  USD240 In stock
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Quality Control
Biological Activity

SKI II is a highly selective and non ATP-competitive S1P receptor inhibitor with IC50 of 0.5 μM, while exhibits no inhibitory on other kinases including PI3K, PKCα and ERK2.

Protocol
Cell Experiment
Cell lines T-24, MCF-7, MCF-7/VP, NCI/ADR cell lines
Preparation method T24, MCF-7, MCF-7/VP, and NCI/ADR cells are plated into 96-well tissue culture plates at ~15% confluency. 24 hours Later, treating the cells are with various concentrations of inhibitors. An additional 48 hours later , cell survival is assayed using the sulforhodamine B assay
Concentrations ~50 μM
Incubation time 48 hours
Animal Experiment
Animal models JC xenografts are established in mice
Formulation DMSO (ip), polyethylene glycol 400 (oral)
Dosages ~100 mg/kg
Administration Intraperitoneal administration or oral administration
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 302.78
Formula C15H11ClN2OS
CAS Number 312636-16-1
Purity 99.36%
Solubility DMSO 50 mg/mL
Storage at -20°C
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: SKI II, SphK-I2 supplier, S1P Receptor, inhibitors

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