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TC-SP 14

Cat. No. M7398
TC-SP 14 Structure
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Quality Control & Documentation
Biological Activity

TC-SP 14 is a potent and selective S1P1 agonist (EC50 values are 0.042 and 3.47 μM for human S1P1 and S1P3 respectively). Attenuates immune response to antigen challenge and reduces circulating blood lymphocyte counts in a rodent model of delayed-type hypersensitivity. Orally bioavailable.

Chemical Information
Molecular Weight 450.5
Formula C25H20F2N2O2S
CAS Number 1257093-40-5
Form Solid
Solubility (25°C) DMSO 22.52 mg/mL (with gentle warming)
Storage RT, dry
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Dukes, et al. J Steroid Biochem Mol Biol. The preclinical pharmacology of "Arimidex" (anastrozole; ZD1033)-a potent, selective aromatase inhibitor.

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Keywords: TC-SP 14 supplier, S1P Receptor, inhibitors, activators

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