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Ponesimod

Cat. No. M5886
Ponesimod Structure
Synonym:

ACT-128800

Size Price Availability Quantity
5mg USD 99  USD110 In stock
10mg USD 162  USD180 In stock
50mg USD 612  USD680 In stock
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Quality Control
Biological Activity

Ponesimod(ACT-128800) is an orally active, selective sphingosine-1-phosphate receptor 1 (S1P1) immunomodulator with EC50 of 5.7 nM.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 460.97
Formula C23H25ClN2O4S
CAS Number 854107-55-4
Purity 99.74%
Solubility 90 mg/mL in DMSO
Storage at -20°C
References

Oral ponesimod in relapsing-remitting multiple sclerosis: a randomised phase II trial.
Olsson T, et al. J Neurol Neurosurg Psychiatry. 2014 Nov;85(11):1198-208. PMID: 24659797.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Ponesimod, ACT-128800 supplier, S1P Receptor, inhibitors

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