| Cat.No. | Name | Information |
|---|---|---|
| M3629 | LY333531 hydrochloride | LY333531 hydrochloride competitively and reversibly inhibits PKCβI and PKCβII (IC50 values are 4.7 and 5.9 nM respectively). |
| M2066 | Staurosporine | Staurosporine (AM-2282) is a potent ATP-competitive kinase inhibitor with IC50 of 0.7, 7, 8.5, 6, 20 nM for PKC, PKA,PKG, p60v-src tyrosine protein kinase, CaM kinase II, respectively. |
| M2850 | Midostaurin | Midostaurin (pkc412) is a multi-targeted kinase inhibitor, including PKCα/β/γ, Syk, Flk-1, Akt, PKA, c-Kit, c-Fgr, c-Src, FLT3, PDFRβ and VEGFR1/2 with IC50 ranging from 80-500 nM. |
| M4647 | Phorbol 12-myristate 13-acetate | Phorbol 12-myristate 13-acetate (PMA) is a dual SphK and protein kinase C (PKC) activator, increases the intracellular Ca2+ concentration ([Ca2+]i) in a dose-dependent manner, with an EC50 of 11.7 nM. |
| M5032 | Zoledronic acid monohydrate | Zoledronic acid monohydrate(CGP 42446; ZOL 446) is an activator of protein kinase C with apoptotic effects on multiple myeloma cell lines. It inhibited proliferation of human foetal osteoblastic cell line (hFOB) with an IC50 of 40 uM. |
| M2329 | Zoledronic acid | Zoledronic Acid (Zoledronate) is a third-generation bisphosphonate (BP), with potent anti-resorptive activity. Zoledronic Acid inhibits the differentiation and apoptosis of osteoclasts. Zoledronic Acid also has anti-cancer effects. |
| M2790 | K252a | K252a is an inhibitor of the BDNF receptor TrkB. K-252a inhibits protein kinase with IC50 values of 470 nM, 140 nM, 270 nM, and 1.7 nM for PKC, PKA, Ca2+/calmodulin-dependent kinase type II, and phosphorylase kinase, respectively. K-252a is a potent inhibitor (IC50 of 3 nM) of the tyrosine protein kinase (TRK) activity of the NGF receptor gp140trk, the product of the trk protooncogene. |
| M3625 | Go6976 | Go6976 is a potent protein kinase C (PKC) inhibitor (IC50 = 7.9 nM), selectively inhibits PKCα and PKCβ1 (IC50 values are 2.3 and 6.2 nM respectively). |
| M10805 | Cercosporin | Cercosporin is produced by the plant pathogenSporakikuchii and elsinochromes, pigments of the elsinoe family of fungi. Cercosporin is an effective photosensitizer with a short activation wavelength that is primarily suitable for surface PDT photodynamic studies (especially for the avoidance of perforation studies). Cercosporin contains the perylenequinone structural features necessary to PKC activity with an IC50 of 0.6-1.3 μM. |
| M10770 | Ruboxistaurin | Ruboxistaurin (LY333531) is an orally active, selective PKC beta inhibitor (Ki=2 nM), ruboxistaurin exhibits ATP-dependent competitive inhibition of PKC beta I, which IC50 4.7 nM. Ruboxistaurin for PKC beta II IC50 5.9 nM. |
| M10490 | Delcasertib | Delcasertib (KAI-9803) is a potent and selective δ-protein kinase C (δPKC) inhibitor, it could ameliorate injury associated with ischemia and reperfusion in animal models of acute myocardial infarction (MI). |
| M9547 | VTX-27 | VTX-27 is a novel potent and selective PKCθ inhibitor, with Kis of 0.08 nM and 16 nM for PKC θ and PKC δ. |
| M9484 | PKCβ inhibitor | PKCβ inhibitor is a potent and selective inhibitor of PKCβ isozymes (IC50 = 5 nM and 21 nM for human PKCβII and βI). |
| M8141 | Rottlerin | Recently, Rottlerin (mallotoxin) has been shown to be a potent activator of the large conductance voltage and Ca2 activated K+ channel and to potently leftward shift the conductance-voltage relationship of the channel. |
| M7837 | Hispidin | Hispidin is a potent inhibitor of protein kinase Cβ, cytotoxic for cancer cells. |
| M7647 | Bryostatin 1 | Bryostatin 1 is a natural macrolide isolated from the moss bug Bugula neritina and a potent PKC modulator of central nervous system (CNS) permeability.Bryostatin 1 binds to the isolated Munc13-1 C1 domain and the full-length Munc13-1 protein with a Ki value of 8.07 and 0.45 nM, respectively, and has anticancer, anti-inflammatory and neuroprotective activities. Bryostatin 1 binds to the isolated C1 domain of Munc13-1 and the full-length Munc13-1 protein with Ki values of 8.07 nM and 0.45 nM, respectively, and exhibits anticancer, anti-inflammatory, and neuroprotective activities. |
| M7163 | Prostratin | Prostratin is a pKC activator, with a Ki of 12.5 nM. Prostratin is also an NF-κB activator, it activates HIV gene expression in T cells. Prostratin is orally available. |
| M7136 | Phorbol 12,13-dibutyrate | Phorbol 12,13-dibutyrate is a protein kinase C activator. |
| M5416 | TPPB | A cell-permeable benzolactam derived PKC activator (Ki = 11.9 nM for PKCα) that efficiently enhances non-amyloidogenic α-processing of amyloid precursor protein (APP) even at 100 nM in human fibroblast AG06848. Displays a marked loss of tumor promoting activity. |
| M5319 | Chelerythrine Chloride | Chelerythrine is potent, cell-permeable inhibitor of protein kinase C (IC50 = 660 nM); competitive with respect to the phosphate acceptor and non-competitive with respect to ATP. |
| M5303 | 1-Naphthyl PP1 | 1-Naphthyl PP1(1-NA-PP 1) is a selective inhibitor of src family kinases v-Src and c-Fyn as well as the tyrosine kinase c-Abl (IC50 values are 1.0, 0.6, 0.6, 18 and 22 μM for v-Src, c-Fyn, c-Abl, CDK2 and CAMK II respectively). |
| M5030 | Ingenol Mebutate | Ingenol Mebutate is a diterpenoid derived from Euphorbia plant and a modulator of PKC with Ki values of 0.3, 0.105, 0.162, 0.376 and 0.171 nM for PKC-α, PKC-β, PKC-γ, PKC-δ and PKC-ε, respectively.In addition, Ingenol Mebutate is a cell death inducer with anticancer activity.Ingenol Mebutate has been shown to be an anticancer agent. Ingenol Mebutate is also an inducer of cell death and has anticancer activity. |
| M4859 | Valrubicin | Valubicin (AD-32) is a chemotherapeutic compound for bladder cancer. |
| M4661 | Chelerythrine | Chelerythrine |
| M4450 | Acteoside | Acteoside is isolated from Acanthus mollis, acts as an ATP-competitive inhibitor of PKC, with an IC50 of 25 µM, and has antitumor, anti-inflammatory and antineuropathic pain activity. |
| M3974 | Ingenol | Ingenol is a extremely weak protein kinase C (PKC) activator. Starting material for synthesis of ingenol derivatives. |
| M3804 | Ro 31-8220 | Ro 31-8220 is a protein kinase C inhibitor, with activity at other protein kinases (IC50 values are 33, 3, 8, 15 and 38 nM for PKCα, MAPKAP-K1b, MSK1, GSK3β and S6K1 respectively). |
| M3803 | Sotrastaurin | Sotrastaurin is a potent and orally-active pan-PKC inhibitor, with Kis of 0.22 nM, 0.64nM, 0.95 nM, 1.8 nM, 2.1 nM and 3.2 nM for PKCθ, PKCβ, PKCα, PKCη, PKCδ and PKCε, respectively. |
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