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Zoledronic acid administration may be a potentially valuable adjunct to distraction osteogenesis treatment, to enhance bone strength, thus reducing refracture complications.Zoledronic acid, a more recent drug, was compared with pamidronic acid in two clinical trials, but the results are unconvincing because of the unusually poor performance of pamidronic acid. Safety of zoledronic acid is uncertain, owing to a lack of long-term data.
Nat Commun. 2023 Mar 14;14(1):1413.
BRD9-mediated chromatin remodeling suppresses osteoclastogenesis through negative feedback mechanism
Zoledronic acid monohydrate purchased from AbMole
| Molecular Weight | 290.1 |
| Formula | C5H12N2O8P2 |
| CAS Number | 165800-06-6 |
| Solubility (25°C) | Water 7 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] A Tomillero, et al. Gateways to clinical trials
[2] A Tomillero, et al. Gateways to clinical trials
[3] A Tomillero, et al. Gateways to clinical trials
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