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Zoledronic acid monohydrate

Cat. No. M5032
Zoledronic acid monohydrate Structure
Synonym:

Zoledronate monohydrate; CGP 42446 monohydrate; CGP42446A monohydrate; ZOL 446 monohydrate

Size Price Availability Quantity
25mg USD 60  USD60 In stock
50mg USD 90  USD90 In stock
100mg USD 150  USD150 In stock
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Quality Control & Documentation
Biological Activity

Zoledronic acid administration may be a potentially valuable adjunct to distraction osteogenesis treatment, to enhance bone strength, thus reducing refracture complications.Zoledronic acid, a more recent drug, was compared with pamidronic acid in two clinical trials, but the results are unconvincing because of the unusually poor performance of pamidronic acid. Safety of zoledronic acid is uncertain, owing to a lack of long-term data.

Product Citations
Chemical Information
Molecular Weight 290.1
Formula C5H12N2O8P2
CAS Number 165800-06-6
Solubility (25°C) water:7 mg/ml
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] A Tomillero, et al. Gateways to clinical trials

[2] A Tomillero, et al. Gateways to clinical trials

[3] A Tomillero, et al. Gateways to clinical trials

[4] M Bays, et al. Gateways to clinical trials

[5] M Bays, et al. Gateways to clinical trials

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Keywords: Zoledronic acid monohydrate, Zoledronate monohydrate; CGP 42446 monohydrate; CGP42446A monohydrate; ZOL 446 monohydrate supplier, PKC, inhibitors, activators


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