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Zoledronic acid monohydrate

Cat. No. M5032
Zoledronic acid monohydrate Structure
Synonym:

Zoledronate monohydrate; CGP 42446 monohydrate; CGP42446A monohydrate; ZOL 446 monohydrate

Size Price Availability Quantity
50mg USD 90  USD90 In stock
100mg USD 170  USD170 In stock
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Quality Control
Biological Activity

Zoledronic acid administration may be a potentially valuable adjunct to distraction osteogenesis treatment, to enhance bone strength, thus reducing refracture complications.Zoledronic acid, a more recent drug, was compared with pamidronic acid in two clinical trials, but the results are unconvincing because of the unusually poor performance of pamidronic acid. Safety of zoledronic acid is uncertain, owing to a lack of long-term data.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 290.1
Formula C5H12N2O8P2
CAS Number 165800-06-6
Purity >98%
Solubility water:7 mg/ml
Storage at -20°C
References

[1] A Tomillero, et al. Gateways to clinical trials

[2] A Tomillero, et al. Gateways to clinical trials

[3] A Tomillero, et al. Gateways to clinical trials

[4] M Bays, et al. Gateways to clinical trials

[5] M Bays, et al. Gateways to clinical trials

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Keywords: Zoledronic acid monohydrate, Zoledronate monohydrate; CGP 42446 monohydrate; CGP42446A monohydrate; ZOL 446 monohydrate supplier, PKC, inhibitors

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