Ingenol has been found to induce apoptosis and act as an anticancer agent. Ingenol derivatives have received constant and multidisciplinary attention on account of their pleiotropic pattern of biological activity.Ingenol is an activator of PKC ε and PKC δ.
Molecular Weight | 348.40 |
Formula | C20H28O5 |
CAS Number | 30220-46-3 |
Solubility (25°C) | DMSO ≥ 60 mg/mL |
Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[1] Courtney E Heron, et al. Ingenol Mebutate and the Treatment of Actinic Keratosis
[2] No authors listed. Ingenol Mebutate
[3] Yasmin Khalfe, et al. Ingenol Mebutate: Expanded Utility
[5] Gillian M Keating. Ingenol mebutate gel 0.015% and 0.05%: in actinic keratosis
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