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Zoledronic acid

Cat. No. M2329
Zoledronic acid Structure

Zometa; Zomera; Zoledronate; CGP 42446; CGP42446A; ZOL 446

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
25mg USD 45  USD45 In stock
50mg USD 70  USD70 In stock
100mg USD 135  USD135 In stock
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Quality Control & Documentation
Biological Activity

Zoledronic Acid is a potent nitrogen-containing bisphosphonates of human foetal osteoblastic cell line with an IC50 of 40 μM. Zoledronic acid induces antiproliferative and apoptotic effects on multiple myeloma cell lines in vitro, by activating protein kinase C, and increases the extracellular calcium concentration. Zoledronic acid and radiation caused a dosedependent and time-dependent decrease in cell viability (approximate 50% growth inhibition values were 48 μM and 20μM for 24 hours and 72 hours, respectively, for zoledronic acid and 500 cGy for radiation).

Product Citations
Chemical Information
Molecular Weight 272.09
Formula C5H10N2O7P2
CAS Number 118072-93-8
Solubility (25°C) Water 4 mg/mL (ultrasonic and warming and adjust pH to 6 with NaOH)
Storage 2-8°C, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Liang Wang, et al. Clin Exp Pharmacol Physiol. The apoptotic effect of Zoledronic acid on the nasopharyngeal carcinoma cells via ROS mediated chloride channel activation

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Keywords: Zoledronic acid, Zometa; Zomera; Zoledronate; CGP 42446; CGP42446A; ZOL 446 supplier, PKC, inhibitors, activators

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