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Zoledronic acid

Cat. No. M2329
Zoledronic acid Structure
Synonym:

Zometa, Zomera

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
25mg USD 53  USD53 In stock
50mg USD 87  USD87 In stock
100mg USD 155  USD155 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Zoledronic acid, one of the most potent nitrogen-containing BPs(bisphosphonates), induces antiproliferative and apoptotic effects on multiple myeloma cell lines in vitro, by activating protein kinase C, and increases the extracellular calcium concentration. Zoledronic acid and radiation caused a dosedependent and time-dependent decrease in cell viability (approximate 50% growth inhibition values were 48 μM and 20μM for 24 hours and 72 hours, respectively, for zoledronic acid and 500 cGy for radiation).

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 272.09
Formula C5H10N2O7P2
CAS Number 118072-93-8
Purity >99%
Solubility Soluble in NaOH
Storage at -20°C
References

[1] Liang Wang, et al. Clin Exp Pharmacol Physiol. The apoptotic effect of Zoledronic acid on the nasopharyngeal carcinoma cells via ROS mediated chloride channel activation

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Zoledronic acid, Zometa, Zomera supplier, PKC, inhibitors

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