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Zoledronic acid

Cat. No. M2329

All AbMole products are for research use only, cannot be used for human consumption.

Zoledronic acid Structure
Synonym:

Zometa; Zomera; Zoledronate; CGP 42446; CGP42446A; ZOL 446

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
10mg USD 30  USD30 In stock
25mg USD 45  USD45 In stock
50mg USD 60  USD60 In stock
100mg USD 90  USD90 In stock
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Quality Control & Documentation
Biological Activity

Zoledronic Acid is a potent nitrogen-containing bisphosphonates of human foetal osteoblastic cell line with an IC50 of 40 μM. Zoledronic acid induces antiproliferative and apoptotic effects on multiple myeloma cell lines in vitro, by activating protein kinase C, and increases the extracellular calcium concentration. Zoledronic acid and radiation caused a dosedependent and time-dependent decrease in cell viability (approximate 50% growth inhibition values were 48 μM and 20μM for 24 hours and 72 hours, respectively, for zoledronic acid and 500 cGy for radiation).

Product Citations
Chemical Information
Molecular Weight 272.09
Formula C5H10N2O7P2
CAS Number 118072-93-8
Solubility (25°C) Water 4 mg/mL (ultrasonic and warming and adjust pH to 6 with NaOH)
Storage 2-8°C, sealed
References

[1] Liang Wang, et al. Clin Exp Pharmacol Physiol. The apoptotic effect of Zoledronic acid on the nasopharyngeal carcinoma cells via ROS mediated chloride channel activation

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Keywords: Zoledronic acid, Zometa; Zomera; Zoledronate; CGP 42446; CGP42446A; ZOL 446 supplier, PKC, inhibitors, activators

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