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Delcasertib

Cat. No. M10490
Delcasertib Structure
Synonym:

KAI-9803; BMS-875944

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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Delcasertib (KAI-9803) is a potent and selective δ-protein kinase C (δPKC) inhibitor, it could ameliorate injury associated with ischemia and reperfusion in animal models of acute myocardial infarction (MI).

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 2880.28
Formula C120H199N45O34S2
CAS Number 949100-39-4
Purity >99%
Solubility DMSO ≥ 60 mg/mL
Storage at -20°C
References

[1] A Michael Lincoff, et al. Eur Heart J. Inhibition of delta-protein kinase C by delcasertib as an adjunct to primary percutaneous coronary intervention for acute anterior ST-segment elevation myocardial infarction: results of the PROTECTION AMI Randomized Controlled Trial

[2] Yoshihiro Miyaji, et al. Drug Metab Dispos. Distribution of KAI-9803, a novel δ-protein kinase C inhibitor, after intravenous administration to rats

[3] Eric Bates, et al. Circulation. Intracoronary KAI-9803 as an adjunct to primary percutaneous coronary intervention for acute ST-segment elevation myocardial infarction

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Delcasertib, KAI-9803; BMS-875944 supplier, PKC, inhibitors

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