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Chelerythrine

Cat. No. M4661
Chelerythrine Structure
Size Price Availability Quantity
20mg USD 180  USD200 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Chelerythrine

Customer Product Validations & Biological Datas
Source Mol Cancer Res (2015). Figure 4. Chelerythrine
Method Cell proliferation assay
Cell Lines 621-101 cells
Concentrations 5 μmol/L
Incubation Time 2 h
Results CI-1040 pretreatment did not abrogate the effects of chelerythrine chloride in 621-101 cells or Tsc2-null MEFs
Source Mol Cancer Res (2015). Figure 3. Chelerythrine
Method Western blot
Cell Lines Tsc2+/+ MEFs
Concentrations 2 μmol/L
Incubation Time 4 h
Results Chelerythrine chloride induced PARP cleavage in Tsc2-null MEFs but not Tsc2-expressing MEFs.
Protocol
Cell Experiment
Cell lines SERCA
Preparation method For the phosphorylation by [32P]Pi, 100 lgmL1 SRV protein in an E2-favoring reaction buffer (20 mM MES-pH 6.0-with 10 mM MgCl2, 2 mM EGTA, and the indicated chelerythrine concentrations) was incubated and 4 mM [32P]Pi were added.
Concentrations 1, 10, 50 and 100 μM
Incubation time 20–40 min,
Animal Experiment
Animal models BALB/c (H2d) mice
Formulation
Dosages 25, 50, 100, and 200 mg/kg
Administration i.p.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 383.83
Formula C21H18ClNO4
CAS Number 34316-15-9
Purity >98%
Solubility DMSO 2 mg/mL
Storage at -20°C
References

Chelerythrine delayed tumor growth and increased survival duration of Dalton's lymphoma bearing BALB/c H(2d) mice by activation of NK cells in vivo.
Kumar S, et al. J Cancer Res Ther. 2015 Oct-Dec;11(4):904-10. PMID: 26881539.

Chelerythrine inhibits the sarco/endoplasmic reticulum Ca(2+)-ATPase and results in cell Ca(2+) imbalance.
Vieira SM, et al. Arch Biochem Biophys. 2015 Mar 15;570:58-65. PMID: 25721495.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Chelerythrine supplier, PKC, inhibitors

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