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Chelerythrine

Cat. No. M4661

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Chelerythrine Structure
Size Price Availability Quantity
20mg USD 200  USD200 In stock
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Quality Control & Documentation
Biological Activity

Chelerythrine

Customer Product Validations & Biological Datas
Source Mol Cancer Res (2015). Figure 4. Chelerythrine
Method Cell proliferation assay
Cell Lines 621-101 cells
Concentrations 5 μmol/L
Incubation Time 2 h
Results CI-1040 pretreatment did not abrogate the effects of chelerythrine chloride in 621-101 cells or Tsc2-null MEFs
Source Mol Cancer Res (2015). Figure 3. Chelerythrine
Method Western blot
Cell Lines Tsc2+/+ MEFs
Concentrations 2 μmol/L
Incubation Time 4 h
Results Chelerythrine chloride induced PARP cleavage in Tsc2-null MEFs but not Tsc2-expressing MEFs.
Protocol (for reference only)
Cell Experiment
Cell lines SERCA
Preparation method For the phosphorylation by [32P]Pi, 100 lgmL1 SRV protein in an E2-favoring reaction buffer (20 mM MES-pH 6.0-with 10 mM MgCl2, 2 mM EGTA, and the indicated chelerythrine concentrations) was incubated and 4 mM [32P]Pi were added.
Concentrations 1, 10, 50 and 100 μM
Incubation time 20–40 min,
Animal Experiment
Animal models BALB/c (H2d) mice
Formulation
Dosages 25, 50, 100, and 200 mg/kg
Administration i.p.
Chemical Information
Molecular Weight 383.83
Formula C21H18ClNO4
CAS Number 34316-15-9
Solubility (25°C) DMSO 2 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Kumar S, et al. J Cancer Res Ther. Chelerythrine delayed tumor growth and increased survival duration of Dalton's lymphoma bearing BALB/c H(2d) mice by activation of NK cells in vivo.

[2] Vieira SM, et al. Arch Biochem Biophys. Chelerythrine inhibits the sarco/endoplasmic reticulum Ca(2+)-ATPase and results in cell Ca(2+) imbalance.

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Keywords: Chelerythrine supplier, PKC, inhibitors, activators

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