|ITE is a potent endogenous agonist of aryl hydrocarbon receptor (AhR), which directly binding to AHR with a Ki of 3 nM.
|α-Galactosyl Ceramide (KRN 7000, alpha-GalCer) is a potent NKT cell stimulator and selective CD1d ligand. α-Galactosylceramide (α-GalCer) is a synthetic glycolipid with antitumorial and immunostimulatory.
|Cyclosporin A is an immunosuppressant that binds to cyclophilin and inhibits calcineurin with an IC50 of 7 nM. cyclosporin A [CsA] binds to the cyclophilin 18 (Cyp18)-CsA complex. the Cyp18-CsA complex recruits calcium-regulated neurophosphatase (CaN), leading to the blocking of cytokine gene transcription in activated T cells. CsA is a highly specific inhibitor of T-cell activation.
|4-Biphenylacetic acid (BPA) is a potential non-steroidal anti-inflammatory agent and forms solid inclusion complex with β-cyclodextrin. Its interaction with quinolone antibacterial agents can induce functional blockade of the γ-aminobutyric acid receptors.
|Fucoxanthin is a carotenoid that occurs naturally in certain algae with anti-obesity, anti-oxidant, anti-diabetic, anticancer and anti-inflammatory activities.
|Picolinic acid (PCL 016)
|PCL016 is a pyridine carboxylate metabolite of tryptophan and acts as an anti-infective and immunomodulator. It acts by binding with the zinc associated with zinc finger proteins to alter their structure and inhibit function.
|Trans-Tranilast is an antiallergic drug, used to treat bronchial asthma, allergic rhinitis and atopic dermatitis.
|Setipiprant (ACT-129968, KYTH-105)
|Setipiprant(ACT-129968, KYTH-105) is a selective, orally available antagonist of the prostaglandin D2 receptor 2 (DP2) that that has been shown to have greater specificity for DP2 (CRTH2) than for DP1.
|Actarit is an orally active immunomodulator used in the treatment of rheumatoid arthritis.
|5-Acetylsalicylic acid, also known as Mesalazine or Mesalamine, is an aminosalicylate anti-inflammatory drug used to treat inflammatory bowel disease.
|Dehydroandrographolide Succinate Potasium Salt
|Dehydroandrographolide Succinate (DAS), extracted from herbal medicine Andrographis paniculata (Burm f) Nees, is widely used for the treatment of viral pneumonia and viral upper respiratory tract infections because of its immunostimulatory, anti-infective and anti-inflammatory effect.
|NLRP3 Inflammasome Inhibitor I
|NLRP3 Inflammasome Inhibitor I, an intermediate substrate in the synthesis of glyburide which is free of the cyclohexylurea moiety involved in insulin release, is a novel inhibitor of the NLRP3 inflammasome.
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