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Cucurbitacin-B

Cat. No. M4616
Cucurbitacin-B Structure
Size Price Availability Quantity
20mg USD 320  USD320 In stock
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Quality Control & Documentation
Biological Activity

Cucurbitacin B is a natural compound with anticancer activity.

Chemical Information
Molecular Weight 558.70
Formula C32H46O8
CAS Number 6199-67-3
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Haoyue Zhang, et al. Cucurbitacin B controls M2 macrophage polarization to suppresses metastasis via targeting JAK-2/STAT3 signalling pathway in colorectal cancer

[2] Putthaporn Kaewmeesri, et al. Cucurbitacin B Diminishes Metastatic Behavior of Cholangiocarcinoma Cells by Suppressing Focal Adhesion Kinase

[3] Hua Luo, et al. Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine

[4] Sukant Garg, et al. Cucurbitacin B and cancer intervention: Chemistry, biology and mechanisms (Review)

[5] Liangkun You, et al. The role of STAT3 in autophagy

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LDV, a tripeptide, is a non-fluorescent analog of LDV-FITC.

Cyclo(RADfK)

Cyclo(RADfK) is a selective α(v)β(3) integrin ligand that has been extensively used for research, therapy, and diagnosis of neoangiogenesis.

Obtustatin

Obtustatin is a non-RGD disintegrin of 41 residues.

Integrin Binding Peptide

Integrin Binding Peptide is derived by fibronectin.

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Abmole Inhibitor Catalog




Keywords: Cucurbitacin-B supplier, Integrin, inhibitors, activators


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