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Orientin

Cat. No. M4614
Orientin Structure
Size Price Availability Quantity
10mg USD 200  USD200 In stock
20mg USD 340  USD340 In stock
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Quality Control & Documentation
Biological Activity

Orientin

Product Citations
Chemical Information
Molecular Weight 448.38
Formula C21H20O11
CAS Number 28608-75-5
Solubility (25°C) 10 mM in DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Li Wang, et al. Orientin mediates protection against MRSA-induced pneumonia by inhibiting Sortase A

[2] Cong Qiu, et al. Orientin and vitexin production by a one-pot enzymatic cascade of a glycosyltransferase and sucrose synthase

[3] Zi-Li Kong, et al. Orientin Protects Podocytes from High Glucose Induced Apoptosis through Mitophagy

[4] Chunmeng Li, et al. Orientin suppresses oxidized low-density lipoproteins induced inflammation and oxidative stress of macrophages in atherosclerosis

[5] Kit Ying Lam, et al. A Review on Medicinal Properties of Orientin

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Keywords: Orientin supplier, Immunology/Inflammation, inhibitors, activators

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