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ITE

Cat. No. M9358

All AbMole products are for research use only, cannot be used for human consumption.

ITE Structure
Size Price Availability Quantity
5mg USD 70  USD70 In stock
10mg USD 110  USD110 In stock
25mg USD 220  USD220 In stock
50mg USD 360  USD360 In stock
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Quality Control & Documentation
Biological Activity

ITE is a potent endogenous agonist of aryl hydrocarbon receptor (AhR), which directly binding to AHR with a Ki of 3 nM. ITE potently inhibits human pulmonary artery endothelial (HPAECs) growth at 10 and 20 µM. ITE (20 µM) elevates CYP1A1 and CYP1B1 mRNA levels and decreases the levels of AhR protein in HPAECs.

In vivo, ITE (200 μg, i.p.) significantly suppresses the development of experimental autoimmune uveitis (EAU) in mice. ITE reduces the proportions of cells expressing IFN-γ, IL-17, or IL-10 in mice. ITE also suppresses the secretion of inflammatory cytokines by LN cells in mice.

Product Citations
Chemical Information
Molecular Weight 286.31
Formula C14H10N2O3S
CAS Number 448906-42-1
Solubility (25°C) DMSO ≥ 25 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Pang LP, et al. Exp Lung Res. ITE inhibits growth of human pulmonary artery endothelial cells.

[2] Nugent LF, et al. Invest Ophthalmol Vis Sci. ITE, a novel endogenous nontoxic aryl hydrocarbon receptor ligand, efficiently suppresses EAU and T-cell-mediated immunity.

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Abmole Inhibitor Catalog




Keywords: ITE supplier, Immunology/Inflammation, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.



Products are for research use only. Not for human use. We do not sell to patients.
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