About 30 results found for searched term "ITE" (0.019 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M1979 | Elvitegravir | Integrase |
| GS-9137, EVG | ||
| Elvitegravir (EVG) is a HIV integrase inhibitor with IC50 of 0.7 nM, 2.8 nM and 1.4 nM for HIV-1 IIIB, HIV-2 EHO and HIV-2 ROD, respectively. | ||
| M22515 | Avidin (from egg white) | Western Blot |
| Immunopure Avidin | ||
| Avidin is homotetrameric protein (68kDa) that is obtained from egg whites. Avidin forms an extremely strong complex with d-biotin (Kd ~ 10-15). This activity has made both avidin and biotin extremely useful labels in immunochemical methods of detection and quantitation. | ||
| M2205 | Macitentan | Endothelin Receptor |
| ACT-064992 | ||
| Macitentan is an orally-active, tissue-targeting dual ET receptor antagonist. | ||
| M2985 | Rolitetracycline | Antibiotic |
| Rolitetracycline is a tetracycline antibiotic, which passively diffuses through porin channels in the bacterial membrane and reversibly binds to the 30S ribosomal subunit, preventing binding of tRNA to the mRNA-ribosome complex, and thus interfering with protein synthesis. | ||
| M3262 | Methotrexate metabolite | Antifolate |
| DAMPA; NSC 131463 | ||
| Methotrexate metabolite is a dihydrofolate reductase potent inhibitor with an IC50 of 1 nM. | ||
| M3584 | D-Mannitol | Others |
| Mannitol; Mannite | ||
| D-Mannitol is an osmotic diuretic agent and a weak renal vasodilator. | ||
| M3640 | BAY 57-1293 | Anti-infection |
| Pritelivir; AIC316 | ||
| BAY 57-1293 is a potent helicase primase inhibitor that exhibites antiviral effect on herpes simplex virus (HSV) with IC50 of 20 nM for both HSV-1 and HSV-2. | ||
| M1561 | Sofosbuvir metabolites GS566500 | Others |
| Sofosbuvir metabolites GS566500 | ||
| M4095 | Notoginsenoside-Fe | Others |
| Notoginseng triterpenes; Ginsenoside Mb | ||
| Notoginsenoside Fe(Notoginsenoside Fe) is a natural compound isolated from the varieties of Marsupium. | ||
| M4150 | Glycitin | Anti-infection |
| Glycitein 7-O-β-glucoside | ||
| Soybean isoflavone (Glycitin) is a natural isoflavone isolated from beans that promotes the proliferation of bone marrow stromal cells and osteoblasts and inhibits the biological functions of bone conversion. Glycitin has antibacterial, antiviral and estrogenic effects. | ||
| M4151 | Glycitein | Others |
| Glycetein | ||
| Glycitein is a soybean (yellow cultivar) isoflavonoid used in study apoptosis and anti-oxidation processes. *This compound is unstable in solutions, freshly prepared is recommended. | ||
| M4493 | Casticin (Vitexicarpin) | STAT |
| Casticin | ||
| Casticin (Vitexicarpin) is a methoxyl flavonoid compound obtained from fructus vitae and has anti-mitotic and anti-inflammatory activities. Casticin inhibits the activation of STAT3. | ||
| M4548 | Vitexin | Autophagy |
| Vitexin is a C-glycosylated flavonoid found in a variety of medicinal plants such as Ficus deltoid and Spirulina (Spirodela polyrhiza). Vitexin has a wide range of pharmacological effects, including antioxidant, anticancer, anti-inflammatory, anti-hyperalgesia and neuroprotective effects. | ||
| M4549 | Glucosyl-vitexin | Others |
| 4 "-O-glucosylvitexin is a bioactive flavonoid extracted from hawthorn leaves. | ||
| M4592 | Xylitol | Autophagy |
| Xylite | ||
| Xylitol can be classified as polyols and sugar alcohols. | ||
| M4746 | Isovitexin | JNK |
| Isovitexin, a flavonoid obtained from Asian rice seeds, has antioxidant and anti-inflammatory activities. Isovitexin acts like an inhibitor of JNK1/2 and inhibits NF-κB activation. | ||
| M5852 | Lifitegrast | Integrin |
| SAR 1118; Xiidra | ||
| Lifitegrast is an antagonist of integrin lymphocyte function associated antigen-1 (LFA-1). The IC50 of Jurkat T cells to icAM-1 was 2.98nM. Lifitegrast blocks the interaction between LFA-1 and ICAM-1, thereby reducing T cell activity and cytokine secretion. | ||
| M7904 | Methiothepin mesylate salt | Others |
| Metitepine mesylate; Ro 8-6837 mesylate | ||
| Methiothepin mesylate salt is a 5-HT1, 5-HT6, 5-HT7 serotonin receptor antagonist, which blocks serotonin autoreceptors. | ||
| M9083 | Disitertide | TGF-beta/Smad |
| P144 | ||
| Disitertide is a TGF-β1 inhibitor. | ||
| M9358 | ITE | Immunology/Inflammation |
| ITE is a potent endogenous agonist of aryl hydrocarbon receptor (AhR), which directly binding to AHR with a Ki of 3 nM. | ||
| M9892 | Trypsin Inhibitor (from chicken egg white) | Peptides |
| Trypsin inhibitor from chicken egg white has been used to produce denatured, oxidized and deglycosylated ovomucoid and used to stimulate patient derived cell cultures for mapping T cell epitopes. | ||
| M10031 | Lysozyme (from egg white) | Enzymes & Coenzymes |
| Lysozyme (from egg white) is a bactericidal enzyme present in chicken eggs, and it lyses gram-positive bacteria. | ||
| M10179 | Vesnarinone | PDE |
| OPC-8212; Piteranometozine; Arkin | ||
| Vesnarinone is a cardiotonic agent, mixed phosphodiesterase 3 inhibitor and ion-channel modifier that has modest, dose-dependent, positive inotropic activity. | ||
| M10270 | Agnuside | Prostaglandin Receptor |
| Vitex negundo oil, Agnuside | ||
| Agnuside is a compound isolated from Vitex negundo with anti-arthritic activity. | ||
| M10407 | PNU-159682 | Topoisomerase |
| PNU159682; metabolite of nemorubicin (MMDX) | ||
| PNU-159682 is a major active metabolite of nemorubicin (MMDX) in human liver microsomes, it is a highly potent DNA topoisomerase I inhibitor with excellent cytotoxicity. PNU-159682 is a potent ADCs cytotoxin. | ||
| M10613 | Vitexin-4-O-glucoside | Others |
| Vitexin-4''-O-glucoside is a flavonoid derived from the leaves of Crataegus pinnatifida. | ||
| M10960 | Ralaniten | Androgen Receptor |
| EPI-002 | ||
| Ralaniten (EPI-002) is an effective and orally active androgen receptor N-terminal domain (AR-NTD) antagonist. Ralaniten inhibits AR transcriptional activity,IC50 The value is 7.4 μM. Ralanites can be used in the study of castration-resistant prostate cancer (CRPC). | ||
| M10961 | Ralaniten triacetate | Androgen Receptor |
| EPI-506 | ||
| Ralaniten triacetate (EPI-506), a prodrug for Ralaniten, is a pioneering, orally active androgen receptor (AR) N-terminal domain (NTD) inhibitor. Ralaniten triacetate is active against full-length and resistance-related AR species, including AR-v7. | ||
| M13411 | GS-443902 trisodium | DNA/RNA Synthesis |
| GS-441524 triphosphate trisodium; Remdesivir metabolite trisodium | ||
| GS-443902 trisodium (GS-441524 triphosphate trisodium) is a potent viral RNA-dependent RNA-polymerases (RdRp) inhibitor with IC50s of 1.1 µM, 5 µM for RSV RdRp and HCV RdRp, respectively. *The compound is unstable in solutions, freshly prepared is recommended | ||
| M13600 | Abemaciclib metabolite M20 | CDK |
| LSN3106726 | ||
| Abemaciclib metabolite M20 (LSN3106726), the active metabolite of Abemaciclib, is a selective CDK4/6 inhibitor for the treatment of cancer. | ||
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