Free shipping on all orders over $ 500

Agnuside

Cat. No. M10270
Agnuside Structure
Synonym:

Vitex negundo oil, Agnuside

Size Price Availability Quantity
5mg USD 230  USD230 In stock
10mg USD 380  USD380 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Agnuside is a compound isolated from Vitex negundo with anti-arthritic activity. Agnuside down-regulates pro-inflammatory mediators PGE2 and LTB4, and reduces the expression of cytokines. Agnuside inhibits COX-2 (IC50: 0.026 mg/ml) but exhibits less than 10% inhibition of COX-1 at this concentration. It also inhibits 46.3, 66.8, and 82.1% of P-glycoprotein (P-gp) ATPase activity at concentrations of 5, 25, and 100 μM, respectively. Agnuside (0.1-10 μM) induces proliferation of MCF-7 breast cancer cells, an effect that is inhibited by the estrogen receptor antagonist fulvestrant.

Chemical Information
Molecular Weight 466.44
Formula C22H26O11
CAS Number 11027-63-7
Form Solid
Solubility (25°C) DMSO
Storage 2-8°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Anjali Pandey, et al. Inflamm Res. Anti-arthritic activity of agnuside mediated through the down-regulation of inflammatory mediators and cytokines

[2] Yuan Hu, et al. J Pharm Pharmacol. Evaluation of the estrogenic activity of the constituents in the fruits of Vitex rotundifolia L. for the potential treatment of premenstrual syndrome

[3] A Suksamrarn, et al. Planta Med. Iridoids with anti-inflammatory activity from Vitex peduncularis

Related Prostaglandin Receptor Products
Carbacyclin

Carbacyclin is a PGI2 analogue, acts as a prostacyclin (PGI2) receptor agonist and vasodilator, and potently inhibits platelet aggregation.

DT-9081

DT-9081 is a potentially best-in-class, orally active, small molecule prostaglandin EP4 receptor antagonist that reverses prostaglandin E2 (PGE2)-induced immunosuppression in certain tumors by blocking the EP4 receptor present on immune cells.

Unoprostone

Unoprostone is a prostaglandin F2α analog (PGAs) that reduces oxidative stress and light-induced retinal cell death as well as phagocytosis dysfunction by activating BK channels. It can be used in studies related to glaucoma or hypertension.

15-keto-Prostaglandin E2

15-keto-Prostaglandin E2 is an endogenous metabolite.

Prostaglandin B1

Prostaglandin B1 (PGB1) is a metabolite of Prostaglandin E1.

  Catalog
Abmole Inhibitor Catalog




Keywords: Agnuside, Vitex negundo oil, Agnuside supplier, Prostaglandin Receptor, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.