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Laquinimod

Cat. No. M1803

All AbMole products are for research use only, cannot be used for human consumption.

Laquinimod Structure
Synonym:

ABR-215062

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
2mg USD 32  USD32 In stock
5mg USD 56  USD56 In stock
10mg USD 88  USD88 In stock
25mg USD 112  USD112 In stock
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Quality Control & Documentation
Biological Activity

Laquinimod (ABR-215062) is a new orally active immunoregulator effectively inhibits development and relapses of experimental autoimmune encephalomyelitis. EAE shares important immunological and clinical features with multiple sclerosis (MS). Doses of 16, 1.6 and 0.16 mg/kg/day laquinimod dose-dependently inhibited disease and showed better disease inhibitory effects as compared to roquinimex (Linomide). Furthermore, laquinimod inhibited the inflammation of both CD4+ T cells and macrophages into central nervous tissues, i.e. the spinal cord. It also changed the cytokine balance in favour of TH2/TH3 cytokines IL-4, IL-10 and TGF-beta.

Chemical Information
Molecular Weight 356.8
Formula C19H17ClN2O3
CAS Number 248281-84-7
Solubility (25°C) DMSO 70 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Toubi et al. J Neuroimmunol. Laquinimod modulates B cells and their regulatory effects on T cells in Multiple Sclerosis.

[2] Brück et al. Acta Neuropathol. Reduced astrocytic NF-κB activation by laquinimod protects from cuprizone-induced demyelination.

[3] Mishra et al. Am J Pathol. Kinetics of proinflammatory monocytes in a model of multiple sclerosis and its perturbation by laquinimod.

[4] Aharoni et al. J Neuroimmunol. Oral treatment with laquinimod augments regulatory T-cells and brain-derived neurotrophic factor expression and reduces injury in the CNS of mice with experimental autoimmune encephalomyelitis.

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Keywords: Laquinimod, ABR-215062 supplier, Immunology/Inflammation, inhibitors, activators

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