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Immunology/Inflammation Immunology/Inflammation

Cat.No.  Name Information
M4614 Orientin Orientin
M9358 ITE ITE is a potent endogenous agonist of aryl hydrocarbon receptor (AhR), which directly binding to AHR with a Ki of 3 nM.
M10093 α-Galactosyl Ceramide α-Galactosyl Ceramide (KRN 7000, alpha-GalCer) is a potent NKT cell stimulator and selective CD1d ligand. α-Galactosylceramide (α-GalCer) is a synthetic glycolipid with antitumorial and immunostimulatory.
M1831 Cyclosporine A Cyclosporin A is an immunosuppressant that binds to cyclophilin and inhibits calcineurin with an IC50 of 7 nM. cyclosporin A [CsA] binds to the cyclophilin 18 (Cyp18)-CsA complex. the Cyp18-CsA complex recruits calcium-regulated neurophosphatase (CaN), leading to the blocking of cytokine gene transcription in activated T cells. CsA is a highly specific inhibitor of T-cell activation.
M20413 4-Biphenylacetic acid 4-Biphenylacetic acid (BPA) is a potential non-steroidal anti-inflammatory agent and forms solid inclusion complex with β-cyclodextrin. Its interaction with quinolone antibacterial agents can induce functional blockade of the γ-aminobutyric acid receptors.
M25413 Fucoxanthin Fucoxanthin is a carotenoid that occurs naturally in certain algae with anti-obesity, anti-oxidant, anti-diabetic, anticancer and anti-inflammatory activities.
M10981 Thymol Thymol is the main monoterpene phenol present in essential oils, which are isolated from plants belonging to the family Lipaceae and other plants such as Verbenaiaceae, Psylliaceae, Buttercupaceae, etc. Thymol has antioxidant, anti-inflammatory, antibacterial and antifungal effects.
M10924 LY-3475070 Ly-3475070 is the first oral bioavailable, selective and extracellular enzyme CD73 (cluster of Differentiation 73, 5'-ecto-nucleotidase, 5' -nt, Ecto -5'-nucleotidase) inhibitor.
M10772 AB-680 AB-680 is a potent, reversible, selective CD73 (extracellular nucleotide enzyme) inhibitor of hCD73 Ki The value is 4.9 pM, which is more than 10,000 times more selective than the associated extracellular nucleotide CD39. Has antitumor activity.
M10573 (+/-)-Lisofylline (±)-Lisofylline is a potent anti-inflammatory agent in which only the (-) optical isomer is biologically active. (±)-Lisofylline was found to inhibit the generation of phosphatidic acid from cytokine-activated lysophosphatidic acyl transferase.
M9730 B7/CD28 interaction inhibitor 1 CTLA-4 inhibitor 1 is a potent B7.1-CD28 interaction inhibitor with IC50 of 50 nM.
M9509 NS-3-008 hydrochloride NS-3-008 hydrochloride is an orally active transcriptional inhibitor of G0/G1 switch 2 (G0s2) with an IC50 of 2.25 μM.
M9298 AX-024 hydrochloride Ax-024 Hydrochloride is orally available, the first tCR-NCK interaction inhibitor that selectively inhibits TCR-induced T cell activation with an IC50 value of 1 nM. Ax-024 Hydrochloride regulates cellular signaling by targeting the SH3 domain. Ax-024 Hydrochloride has the characteristics of low toxicity, high efficiency and high selectivity.
M9122 Tormentic Acid Tormentic Acid is a natural anti-inflammatory agent which inhibits production of tumor necrosis factor‑α (TNF‑α), interleukin 6 (IL‑6), and IL‑1β.
M9117 W-54011 W-54011 is a potent, specific, and orally active CD88 (C5a receptor) antagonist, which inhibits the binding of 125I-labeled C5a to human neutrophils with a Ki value of 2.2 nM.
M9052 ST2825 ST-2825 is MyD88 inhibitor.
M5707 Indoprofen Indoprofen is a non-steroidal anti-inflammatory compound, provide insight into treatments for spinal muscular atrophies.
M4877 Karminomitsin Karminomitsin is a very toxic anthracycline-type antineoplastic related to DAUNORUBICIN, obtained from Actinomadura carminata.
M4825 SKQ1  SKQ1 is a potent mitochondria-targeted antioxidant.
M4791 Tussilagone Tussilagone is a major active component in Tussilago farfara, has anti-inflammatory effect.
M4790 β-demonic-acid β-demonic-acid exhibits anti-inflammatory effects.
M4750 Echinocystic-acid Echinocystic-acid
M4724 Leonurine hydrochloride Leonurine hydrochloride is an alkaloid isolated from Herba leonuri, with anti-oxidative and anti-inflammatory.
M4686 Eriodictyol Eriodictyol is a flavonoid obtained from Chinese herbs, which has antioxidant and anti-inflammatory properties. Eriodictyol can induce Nrf2 signaling pathway. Eriodictyol is also an influenza dependent RNA polymerase inhibitor with an IC50 of 18 nM.
M4389 Carnosol Carnosol is a phenolic diterpene with antioxidant and anticarcinogenic activities.
M4139 Salvianolic-acid-A Salvianolic-acid-A

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