| Cat.No. | Name | Information |
|---|---|---|
| M4614 | Orientin | Orientin |
| M9358 | ITE | ITE is a potent endogenous agonist of aryl hydrocarbon receptor (AhR), which directly binding to AHR with a Ki of 3 nM. |
| M10093 | α-Galactosyl Ceramide | α-Galactosyl Ceramide (KRN 7000, alpha-GalCer) is a potent NKT cell stimulator and selective CD1d ligand. α-Galactosylceramide (α-GalCer) is a synthetic glycolipid with antitumorial and immunostimulatory. |
| M1831 | Cyclosporine A | Cyclosporine A (CsA，Cyclosporin A) is an immunosuppressant that binds to cyclophilin and inhibits calcineurin with an IC50 of 7 nM. Cyclosporine A [CsA] binds to the cyclophilin 18 (Cyp18)-CsA complex. the Cyp18-CsA complex recruits calcium-regulated neurophosphatase (CaN), leading to the blocking of cytokine gene transcription in activated T cells. CsA is a highly specific inhibitor of T-cell activation. |
| M20413 | 4-Biphenylacetic acid | 4-Biphenylacetic acid (BPA) is a potential non-steroidal anti-inflammatory agent and forms solid inclusion complex with β-cyclodextrin. Its interaction with quinolone antibacterial agents can induce functional blockade of the γ-aminobutyric acid receptors. |
| M25413 | Fucoxanthin | Fucoxanthin is a carotenoid that occurs naturally in certain algae with anti-obesity, anti-oxidant, anti-diabetic, anticancer and anti-inflammatory activities. |
| M55368 | 2-Hydroxy Fluorene | 2-Hydroxy Fluorene (2-FLU) has a wide range of applications in life science related research. 2-FLU can increase the expression of psoriasis-related inflammatory factors in HaCaT cells. |
| M20433 | Tolmetin | Tolmetin is a nonsteroidal anti-inflammatory drug of the heterocyclic acetic acid derivative class and also exhibits analgesic and antipyretic activity. |
| M20432 | 5-Acetylsalicylic acid | 5-Acetylsalicylic acid is an aminosalicylate anti-inflammatory agent, which has anti-inflammatory and is considered to be the active agent in inflammatory bowel disease (IBD). |
| M20412 | NLRP3 Inflammasome Inhibitor I | NLRP3 Inflammasome Inhibitor I, an intermediate substrate in the synthesis of glyburide which is free of the cyclohexylurea moiety involved in insulin release, is a novel inhibitor of the NLRP3 inflammasome. |
| M18961 | Cistanoside F | Cistanoside F is a phenylethanoid glycosid isolated from Cistanche deserticola, with antioxidative effect. |
| M18678 | Ginsenoside Rk2 | Ginsenoside Rk2 is a dammarane glycoside isolated from the processed ginseng (SG; Sun Ginseng), with anti-tumor, and anti-platelet aggregation activities. |
| M18258 | 11beta,13-Dihydrolactucin | 11beta,13-Dihydrolactucin is a sesquiterpene lactone obtained by formal hydrogenation across the 11,13-double bond of lactucin. Found in chicory It has a role as a plant metabolite. |
| M16766 | Cirsilineol | Cirsilineol is a natural flavone compound, which selectively inhibits IFN-γ/STAT1/T-bet signaling in intestinal CD4+ T cells. Cirsilineol has potent immunosuppressive and anti-tumor properties. |
| M16307 | Isogosferol | Isogosferol is a potent anti-inflammatory agent. Isogosferol decreases LPS-stimulated NO and IL-1β expression. Isogosferol decreases the LPS-stimulated expression of iNOS, COX-2, NF-κB, and pERK1/2. |
| M14095 | T6167923 | T6167923 is a potent and selective inhibitor of MyD88-dependent signaling pathways. |
| M11481 | Abatacept | Abatacept is a soluble fusion protein consisting of the extra-cellular domain of human CTLA4 and a fragment of the Fc portion of human IgG1. Abatacept binds to antigen presenting cells CD80 and CD86, blocks costimulatory signals and inhibits T cell activation, and is used in the study of rheumatoid arthritis and juvenile rheumatoid arthritis. |
| M10981 | Thymol | Thymol is the main monoterpene phenol present in essential oils, which are isolated from plants belonging to the family Lipaceae and other plants such as Verbenaiaceae, Psylliaceae, Buttercupaceae, etc. Thymol has antioxidant, anti-inflammatory, antibacterial and antifungal effects. |
| M10924 | LY-3475070 | Ly-3475070 is the first oral bioavailable, selective and extracellular enzyme CD73 (cluster of Differentiation 73, 5'-ecto-nucleotidase, 5' -nt, Ecto -5'-nucleotidase) inhibitor. |
| M10772 | AB-680 | AB-680 is a potent, reversible, selective CD73 (extracellular nucleotide enzyme) inhibitor of hCD73 Ki The value is 4.9 pM, which is more than 10,000 times more selective than the associated extracellular nucleotide CD39. Has antitumor activity. |
| M10573 | (+/-)-Lisofylline | (±)-Lisofylline is a potent anti-inflammatory agent in which only the (-) optical isomer is biologically active. (±)-Lisofylline was found to inhibit the generation of phosphatidic acid from cytokine-activated lysophosphatidic acyl transferase. |
| M9730 | B7/CD28 interaction inhibitor 1 | B7/CD28 interaction inhibitor 1 is a potent B7.1-CD28 interaction inhibitor with IC50 of 50 nM. |
| M9509 | NS-3-008 hydrochloride | NS-3-008 hydrochloride is an orally active transcriptional inhibitor of G0/G1 switch 2 (G0s2) with an IC50 of 2.25 μM. |
| M9333 | Phytohemagglutinin | Phytohemagglutinin is a lectin obtained from the red kidney bean that binds to the membranes of T-cells, stimulates metabolic activity and involves inflammatory pathways. Phytohemagglutinin is a T-cell activator. |
| M9298 | AX-024 hydrochloride | Ax-024 Hydrochloride is orally available, the first tCR-NCK interaction inhibitor that selectively inhibits TCR-induced T cell activation with an IC50 value of 1 nM. Ax-024 Hydrochloride regulates cellular signaling by targeting the SH3 domain. Ax-024 Hydrochloride has the characteristics of low toxicity, high efficiency and high selectivity. |
| M9122 | Tormentic Acid | Tormentic Acid is a natural anti-inflammatory agent which inhibits production of tumor necrosis factor‑α (TNF‑α), interleukin 6 (IL‑6), and IL‑1β. |
| M9117 | W-54011 | W-54011 is a potent, specific, and orally active CD88 (C5a receptor) antagonist, which inhibits the binding of 125I-labeled C5a to human neutrophils with a Ki value of 2.2 nM. |
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