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NS-3-008 hydrochloride

Cat. No. M9509
NS-3-008 hydrochloride Structure
Synonym:

NS-3-008 hcl

Size Price Availability Quantity
5mg USD 75  USD75 In stock
10mg USD 110  USD110 In stock
25mg USD 210  USD210 In stock
50mg USD 355  USD355 In stock
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Quality Control & Documentation
Biological Activity

NS-3-008 hydrochloride is an orally active transcriptional inhibitor of G0/G1 switch 2 (G0s2) with an IC50 of 2.25 μM. NS-3-008 decreases the nuclear phosphorylation of Stat5.

In vivo, NS-3-008 (5 mg/kg; oral administration; daily; for 4 weeks; wild-type 5/6Nx mice) treatment results in decreased levels of G0s2 and Ccl2 mRNA in the kidneys.

Chemical Information
Molecular Weight 269.81
Formula C14H24ClN3
CAS Number 1172854-54-4
Solubility (25°C) DMSO ≥ 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Matsunaga N, et al. EBioMedicine. Inhibition of G0/G1 Switch 2 Ameliorates Renal Inflammation in Chronic Kidney Disease.

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Keywords: NS-3-008 hydrochloride, NS-3-008 hcl supplier, Immunology/Inflammation, inhibitors, activators


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