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Tormentic Acid is a natural anti-inflammatory agent which inhibits production of tumor necrosis factor-α (TNF-α), interleukin 6 (IL-6), and IL-1β. Tormentic Acid suppresses the NF-κB signaling pathway. Tormentic acid has anti-inflammatory activity, it potently inhibits the production of nitric oxide (NO) in RAW 264.7 cells, also suppresses the LPS-stimulated degradation and phosphorylation of inhibitor of kappa B-α (IκB-α), suggests that the anti-inflammatory activity of TA is associated with the down-regulation of iNOS, COX-2, and TNF-α through the negative regulation of the NF-κB pathway in RAW 264.7 cells. Tormentic acid has protective effect against lipopolysaccharide/D-galactosamine induced fulminant hepatic failure in mice.
| Molecular Weight | 488.70 |
| Formula | C30H48O5 |
| CAS Number | 13850-16-3 |
| Solubility (25°C) | DMSO 10 mM |
| Storage | 2-8°C |
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