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Tolmetin

Cat. No. M20433
Tolmetin Structure
Synonym:

Tolectin

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Quality Control & Documentation
Biological Activity

Tolmetin is a nonsteroidal anti-inflammatory drug of the heterocyclic acetic acid derivative class and also exhibits analgesic and antipyretic activity.

Chemical Information
Molecular Weight 257.28
Formula C15H15NO3
CAS Number 26171-23-3
Solubility (25°C) DMSO 51 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] V Palop, et al. Ann Pharmacother. Tolmetin-induced esophageal ulceration

[2] J M Grindel. Drug Metab Rev. The pharmacokinetic and metabolic profile of the antiinflammatory agent tolmetin in laboratory animals and man

[3] R Sagraves, et al. Drug Intell Clin Pharm. Tolmetin in breast milk

[4] C Restivo, et al. JAMA. Anaphylaxis from tolmetin

[5] R N Brogden, et al. Drugs. Tolmetin: a review of its pharmacological properties and therapeutic efficacy in rheumatic diseases

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Keywords: Tolmetin, Tolectin supplier, Immunology/Inflammation, inhibitors, activators

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