Tolmetin is a nonsteroidal anti-inflammatory drug of the heterocyclic acetic acid derivative class and also exhibits analgesic and antipyretic activity.
|Solubility (25°C)||DMSO 51 mg/mL|
Powder -20°C 3 years ; 4°C 2 years
In solvent -80°C 6 months ; -20°C 1 month
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
 V Palop, et al. Ann Pharmacother. Tolmetin-induced esophageal ulceration
 J M Grindel. Drug Metab Rev. The pharmacokinetic and metabolic profile of the antiinflammatory agent tolmetin in laboratory animals and man
 R Sagraves, et al. Drug Intell Clin Pharm. Tolmetin in breast milk
 C Restivo, et al. JAMA. Anaphylaxis from tolmetin
 R N Brogden, et al. Drugs. Tolmetin: a review of its pharmacological properties and therapeutic efficacy in rheumatic diseases
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