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B7/CD28 interaction inhibitor 1

Cat. No. M9730
B7/CD28 interaction inhibitor 1 Structure

ABM-24720; CTLA-4 - inhibitor

Size Price Availability
5mg USD 230  USD230 4-7 Days
10mg USD 380  USD380 4-7 Days
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Quality Control & Documentation
Biological Activity

CTLA-4 inhibitor 1 is a potent B7.1-CD28 interaction inhibitor with IC50 of 50 nM. Blocking B7/CD28 interactions with monoclonal antibodies or soluble receptors results in immunosuppression and enhanced allograft survival, while B7/CTLA-4 blockade results in enhanced antitumor immune responses. The interaction of co-stimulatory molecules on T cells with B7 molecules on antigen presenting cells plays an important role in the activation of naive T cells.

Chemical Information
Molecular Weight 427.35
Formula C21H13F4N5O
CAS Number 635324-72-0
Form Solid
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Neal J Green, et al. Bioorg Med Chem. Structure-activity studies of a series of dipyrazolo[3,4-b:3',4'-d]pyridin-3-ones binding to the immune regulatory protein B7.1

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Keywords: B7/CD28 interaction inhibitor 1, ABM-24720; CTLA-4 - inhibitor supplier, Immunology/Inflammation, inhibitors, activators

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